Results 211 to 220 of about 68,371 (307)
Fostering childhood prosociality and relatedness: the perceived impact of an arts-based philosophical intervention on collaboration, empathy and respect. [PDF]
Front Health ServGilbert M +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Registered professional nurses' experiences regarding supervision of nursing care at selected hospitals of Limpopo province. [PDF]
CurationisRaliphaswa MR, Luhalima TR, Mafumo JL.
europepmc +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Macro- and Micro-Level Behavioral Patterns in Simulation-Based Scientific Inquiry: Linking Processes to Performance Among Elementary Students. [PDF]
J IntellWang S, Hu A, Yuan L, Tian W, Xin T.
europepmc +1 more source
A Model of Skill Acquisition: An Inquiry into the Effect of Skill Variety on Educational Choice
A Model of Skill Acquisition: An Inquiry into the Effect of Skill Variety on Educational ChoiceWhile numerous studies have specifically examined the role of education as an investment, a signal, or a consumption, this paper addresses another important aspect of education: it provides people with prospects for their future. Through education, people become able to obtain information about their own abilities and aptitudes, which facilitates their
openaire
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Basic Thinking Skills and Their Direct Instructional Approaches: A Narrative Review. [PDF]
Adv Med Educ PractVafamehr V, Haghani F, Jamshidian S.
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source