Results 111 to 120 of about 45,101 (293)
Molecular Therapy: Nucleic Acids, 2017 In early gene therapy trials for SCID-X1, using γ-retroviral vectors, T cell leukemias developed in a subset of patients secondary to insertional proto-oncogene activation.
Samantha L. Ginn +14 more
doaj +1 more source
A History of Cancer Research: Retroviral Insertional Mutagenesis. [PDF]
Cold Spring Harb Perspect Biol, 2023 Lipsick J.
europepmc +1 more source
The Toxoplasma gondii active serine hydrolase 4 regulates parasite division and intravacuolar parasite architecture [PDF]
, 2018 Hydrolase are enzymes that regulate diverse biological processes, including posttranslational protein modifications. Recent work identified four active serine hydrolases (ASHs) in Toxoplasma gondii as candidate depalmitoylases. However, only TgPPT1 (ASH1)
Amara, Neri +7 more
core +2 more sources
Molecular characterization of the A52 murine hepatocellular carcinoma cell line
Animal Models and Experimental Medicine, EarlyView.Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman +5 more
wiley +1 more source
Food and feed safety aspects of cisgenic crop plant varieties [PDF]
This report presents the results of the discussions that identified food and feed safety aspects of cisgenic plant varieties in comparison to conventional varieties on the one hand and transgenic plant varieties on the other hand.
Kok, E.J., Prins, T.W.
core +2 more sources
The power of many: when genetics met yeasts and high‐throughput
Biological Reviews, EarlyView.ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
wiley +1 more source
AAV Vectors, Insertional Mutagenesis, and Cancer
Molecular Therapy, 2007 By now we have all heard a lot about retroviral vectors and cancer, but other types of vectors have typically been left out of these discussions. However, results presented at the recent American Society of Gene Therapy meeting and just published in Science1 show that this is a subject that goes beyond retroviruses, hematopoietic cells, and gamma C ...
openaire +2 more sources
Evaluation of gene editing in CHO cells using the Cas‐CLOVER system
Biotechnology Progress, EarlyView.Abstract Recent advances in gene editing technologies have transformed the genetic engineering of Chinese hamster ovary (CHO) hosts, enabling the development of cell lines with improved stability and productivity. In this study, we employed the programmable nuclease (PN) Cas‐CLOVER to precisely target the Glutamine synthetase (GS) locus in CHO cells. A
Tiffany McLamarrah +13 more
wiley +1 more source
Validation-Based Insertional Mutagenesis (VBIM), A Powerful Forward Genetic Screening Strategy. [PDF]
Curr Protoc, 2022 De S, Tamagno I, Stark GR, Jackson MW.
europepmc +1 more source
The C‐Terminal Regions of TRAK Proteins Contain MIRO‐Independent Mitochondrial Localization Domains
Cytoskeleton, EarlyView.ABSTRACT Current models suggest that MIRO GTPases anchor cytoskeletal motors to the mitochondrial outer membrane (MOM). However, our previous findings indicate that the unconventional myosin, MYO19, interacts with MIRO weakly and that a MIRO‐independent MOM‐localizing domain interacts more tightly with the MOM.
Lili Mitchell +4 more
wiley +1 more source