Results 111 to 120 of about 5,219,627 (290)

Romanian insight [PDF]

British Dental Journal, 2021
C B, Bellu, I F, Dragan, S, Serban
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Matching plus regression adjustment for the estimation of the average treatment effect on survival outcomes: a case study with mosunetuzumab in relapsed/refractory follicular lymphoma

BMC Medical Research Methodology
Background and objectives The National Institute for Health and Care Excellence (England’s health technology assessment body) recommend the use of the average treatment effect (ATE) as an estimand for economic evaluations.
Danilo Di Maio, S. A. Mitchell, S. Batson, E. Keeney, Howard H. Z. Thom   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Patchy signals: capturing women’s voices in mobile phone surveys of rural India

BMJ Global Health, 2021
Skye Hersh, Divya Nair, Pradyot Bharadwaj Komaragiri, Raghav Kapoor Adlakha   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Diagnóstico matemático de la monitoría fetal aplicando la Ley Zipf-Mandelbrot

Revista de la Facultad de Medicina, 2006
Antecedentes. El actual diagnóstico clínico de la monitoría fetal presenta problemas de objetividad y reproducibilidad, sin embargo el análisis físico y matemático del trazado lleva a caracterizaciones objetivas y reproducibles de la dinámica cardíaca ...
Javier Rodríguez Velásquez, Signed Prieto Bohórquez, Liliana Ortíz Salamanca, Alejandro Bautista Charry, Pedro Bernal, Nicolás Avilán Vargas   +5 more
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

"In Defense of Pure Reason: A Rationalist Account of A Priori Justification" by Laurence BonJour [PDF]

, 2003
Laurence BonJour divides approaches to a priori justification into three kinds. Quine’s radical empiricism denies the existence of any special category of a priori justification; moderate empiricism attempts to explain a priori ...
Crane, Tim
core  

An insight into polarization states of solid-state organic lasers

, 2012
The polarization states of lasers are crucial issues both for practical applications and fundamental research. In general, they depend in a combined manner on the properties of the gain material and on the structure of the electromagnetic modes.
A. Brosseau, A. Matsko, B. Valeur, C. Lafargue, C. Ulysse, G. Clavier, I. Gozhyk, J. R. Lakowicz, J. Zyss, J.-F. Audibert, M. Dvorko, M. Lebental, O. Svelto, R. Méallet-Renault, R. Pansu, S. Chénais, S. Forget, S. Lozenko, V. Tsvirkun   +18 more
core   +2 more sources