Results 111 to 120 of about 3,987,444 (239)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Patchy signals: capturing women’s voices in mobile phone surveys of rural India

BMJ Global Health, 2021
Skye Hersh, Divya Nair, Pradyot Bharadwaj Komaragiri, Raghav Kapoor Adlakha   +3 more
doaj   +1 more source

"In Defense of Pure Reason: A Rationalist Account of A Priori Justification" by Laurence BonJour [PDF]

, 2003
Laurence BonJour divides approaches to a priori justification into three kinds. Quine’s radical empiricism denies the existence of any special category of a priori justification; moderate empiricism attempts to explain a priori ...
Crane, Tim
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Diagnóstico matemático de la monitoría fetal aplicando la Ley Zipf-Mandelbrot

Revista de la Facultad de Medicina, 2006
Antecedentes. El actual diagnóstico clínico de la monitoría fetal presenta problemas de objetividad y reproducibilidad, sin embargo el análisis físico y matemático del trazado lleva a caracterizaciones objetivas y reproducibles de la dinámica cardíaca ...
Javier Rodríguez Velásquez, Signed Prieto Bohórquez, Liliana Ortíz Salamanca, Alejandro Bautista Charry, Pedro Bernal, Nicolás Avilán Vargas   +5 more
doaj  

Insight into organic education [PDF]

, 2010
This paper summarizes the research project iPOPY, emphasising main results from all WPs.
Spencer, Tom
core  

Superconformal symmetry and higher-derivative Lagrangians

, 2013
Superconformal methods are useful to build invariant actions in supergravity. We have a good insight in the possibilities of actions that are at most quadratic in spacetime derivatives, but insight in general higher-derivative actions is missing ...
Van Proeyen, Antoine
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Reciprocal Interactions Between Periodontal Disease and Alzheimer’s Disease: Implications for Mutual Triggering, Exacerbation, and Treatment Interventions—A Comprehensive Review of the Literature

Neurology International
Periodontal health is connected to many systemic diseases, such as cardiovascular, diabetes mellitus, and neurodegenerative diseases. The oral–brain axis has gained increasing interest in the pathogenesis of diseases.
Shatha Gharaibeh, Alameen Alsabbah, Ahmad Alloubani, Abeer Gharaibeh   +3 more
doaj   +1 more source