Results 101 to 110 of about 904,380 (360)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Ortadoğu'da Devrimler ve Karışıklıklar
Türkiye Ortadoğu Çalışmaları Dergisi, 2016 Revolutions and Instabilities in the Middle East isimli kitabın incelemesidir.
Kulpunai Barakanova
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Laboratory modeling of MHD accretion disks
Comptes Rendus. PhysiqueThis review article summarizes two decades of laboratory research aimed at understanding the dynamics of accretion disks, with particular emphasis on magnetohydrodynamic experiments involving liquid metals and plasmas.
Gissinger, Christophe
doaj +1 more source
Earthquake-induced coastal sediment instabilities in the western Gulf of Corinth, Greece
, 2002 On June 15 1995, a locally 6.2-R destructive earthquake occurred in the western Gulf of Corinth and caused extensive onshore and offshore sediment instabilities. A detailed offshore geophysical survey along the Tolofonas/Eratini coastline, soon after the
G. FERENTINOS +9 more
core +1 more source
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Zooming in on cluster radio relics
Astronomy & AstrophysicsIt is generally accepted that radio relics are the result of synchrotron emission from shock-accelerated electrons. However, current models are still unable to explain several aspects of their formation.
Whittingham Joseph +4 more
doaj +1 more source
Hydrodynamics, heat transfer and flow boiling instabilities in microchannels [PDF]
, 2010 Boiling in microchannels is a very efficient mode of heat transfer with high heat and mass transfer coefficients achieved. Less pumping power is required for two-phase flows than for single-phase liquid flows to achieve a given heat removal ...
Barber, Jacqueline Claire
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Coexistence of coagulation and streaming instabilities in protoplanetary disks
Astronomy & AstrophysicsThe streaming instability is considered to be one of the leading candidates for the formation of planetesimals, given its ability to overcome the bouncing and fragmentation barriers.
Pierens Arnaud +3 more
doaj +1 more source