Results 91 to 100 of about 904,380 (360)
Cavitation instabilities in bulk metallic glasses
, 2013 To reveal the mechanism of a void-dominated fracture process in bulk metallic glasses, a theoretical description of void growth undergoing remote hydrostatic tension is presented. Special attention is focused on cavitation instabilities and dynamics of a
黄鑫 +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Eigenmode initialisation of 2D (magneto)hydrodynamic simulations
Astronomy & AstrophysicsAims. The early evolution of unstable hydrodynamic and magnetohydrodynamic equilibria is often governed by a few dominant linear eigenmodes. We investigate whether initialising a simulation with a superposition of linear eigenmodes that contains the most
De Jonghe J., Russell A. J. B.
doaj +1 more source
Hierarchical structure of the interstellar molecular clouds and star formation
Open Astronomy, 2017 Properties of the hierarchical structures of interstellar molecular clouds are discussed. Particular attention is paid to the statistical correlations between velocity dispersion and size, and between the magnetic field strength and gas density.
Dudorov Alexander E. +1 more
doaj +1 more source
Amplifying the response of soft actuators by harnessing snap-through instabilities
Proceedings of the National Academy of Sciences of the United States of America, 2015 Significance Although instabilities have traditionally been avoided as they often represent mechanical failure, here we embrace them to amplify the response of fluidic soft actuators.
J. Overvelde +3 more
semanticscholar +1 more source
Interfacial instabilities: implications for multi-material moulding [PDF]
This work investigates and identifies the mechanisms that are at work in the creation of instabilities during co-injection moulding. Two aspects are investigated, neither of which has been previously reported.
Goodship, Vannessa
core
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Streaming Instabilities in Protoplanetary Disks [PDF]
, 2004 Interpenetrating streams of solids and gas in a Keplerian disk produce a local, linear instability. The two components mutually interact via aerodynamic drag, which generates radial drift and triggers unstable modes.
A. Youdin, J. Goodman
semanticscholar +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Whipping Instabilities in Electrified Liquid Jets
, 2008 A liquid jet may develop different types of instabilities, like the so-called Rayleigh-Plateau instability, which breaks the jet into droplets. However, another type of instabilities may appear when we electrify a liquid jet and induce some charge at his
Riboux, Guillaume +3 more
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