Results 71 to 80 of about 904,380 (360)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Near quenching limit instabilities of concurrent flame spread over thin solid fuel
, 2016 Near quenching limit instabilities of concurrent flame spread over thin cellulosic fuel are experimentally studied by employing a narrow channel apparatus.
Zhu KC +4 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Beta‐Dependent Constraints on Ion Temperature Anisotropy in Jupiter’s Magnetosheath
Geophysical Research Letters, 2022 Most space plasmas are weakly collisional. Due to the low collision rate, the plasmas are routinely out of local thermal equilibrium and often exhibit non‐Maxwellian velocity distributions.
R. Bandyopadhyay +9 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Cosmic rays escape from their sources
Frontiers in Astronomy and Space SciencesCosmic rays (CRs) are accelerated in diverse astrophysical objects like supernova remnants, massive star clusters, or pulsars. Fermi acceleration mechanisms built a power-law distribution controlled by the ratio of the acceleration to escape timescales ...
A. Marcowith
doaj +1 more source
The small-scale structure of the Magellanic stream as a foundation for galaxy evolution [PDF]
Serbian Astronomical Journal, 2010 The Magellanic Stream (MS) is the nearest example of a gaseous trail formed by interacting galaxies. While the substantial gas masses in these kinds of circumgalactic structures are postulated to represent important sources of fuel for future star ...
Stanimirović S. +2 more
doaj +1 more source
The interplay between submesoscale instabilities and turbulence in the surface layer of the Bay of Bengal [PDF]
, 2016 The Air-Sea Interactions Regional Initiative (ASIRI) aims to understand vertical fluxes of momentum and heat across the surface layer in the Bay of Bengal.
Pham, HT +15 more
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source