Results 51 to 60 of about 904,380 (360)

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli   +3 more
wiley   +1 more source

Electron-Driven Instabilities in the Solar Wind

open access: yesFrontiers in Astronomy and Space Sciences, 2022
The electrons are an essential particle species in the solar wind. They often exhibit non-equilibrium features in their velocity distribution function.
Daniel Verscharen   +17 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Exploiting Microstructural Instabilities in Solids and Structures: From Metamaterials to Structural Transitions

open access: yes, 2017
Instabilities in solids and structures are ubiquitous across all length and time scales, and engineering design principles have commonly aimed at preventing instability.
D. Kochmann, K. Bertoldi
semanticscholar   +1 more source

Numerical simulation of shear-induced instabilities in internal solitary waves

open access: yes, 2011
This work was supported by the UK Engineering and Physical Sciences Research Council [grant number EP/F030622/1]A numerical method that employs a combination of contour advection and pseudo-spectral techniques is used to simulate shear-induced ...
King, Stuart Edward   +5 more
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Shear instabilities in shallow-water magnetohydrodynamics [PDF]

open access: yes, 2013
The interaction of horizontal shear flows and magnetic fields in stably stratified layers is central to many problems in astrophysical fluid dynamics.
Mak, Julian
core  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A linear dispersion relation for the hybrid kinetic-ion/fluid-electron model of plasma physics

open access: yesNew Journal of Physics, 2016
A dispersion relation for a commonly used hybrid model of plasma physics is developed, which combines fully kinetic ions and a massless-electron fluid description.
D Told, J Cookmeyer, P Astfalk, F Jenko
doaj   +1 more source

The curse of instability

open access: yesComplexity, 2015
High-dimensional computational challenges are frequently explained via the curse of dimensionality, i.e., increasing the number of dimensions leads to exponentially growing computational complexity. In this commentary, we argue that thinking on a different level helps to understand, why we face the curse of dimensionality.
openaire   +2 more sources

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