Results 101 to 110 of about 3,165,406 (373)
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Applied SciencesSurface subsidence induced by underground mining in mining areas significantly alters surface topography and hydrogeological conditions, forming depressions and fissures, thereby affecting regional runoff-ponding processes and groundwater infiltration ...
Shihui Jiao +6 more
doaj +1 more source
Numerical Simulation on Damage and Failure Mechanism of Rock under Combined Multiple Strain Rates
Shock and Vibration, 2018 During underground hard-rock mining, the drilling and blasting method currently remains the most economical excavation method, and the rock may experience a multistrain-rate spectrum under quasi-static, dynamic, and rheological loading conditions and ...
Wancheng Zhu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
doaj +1 more source
Small Structures via Thermal Instability of Partially Ionized Plasma. I. Condensation Mode
, 2007 (Shortened) Thermal instability of partially ionized plasma is investigated by linear perturbation analysis. According to the previous studies under the one fluid approach, the thermal instability is suppressed due to the magnetic pressure.
Davis R. J. +6 more
core +1 more source
The Astrophysical Journal, 2004 We consider the stability of a configuration consisting of a vertical magnetic field in a planar flow on elliptical streamlines in ideal hydromagnetics. In the absence of a magnetic field the elliptical flow is universally unstable (the ``elliptical instability'').
Norman R. Lebovitz, Ellen G. Zweibel
openaire +2 more sources
Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
wiley +1 more source
Discussion: “Collapse by Instability of Thin Cylindrical Shells Under External Pressure” (Windenburg, Dwight F., and Trilling, Charles, 1934, Trans. ASME, 56, pp. 819–825) [PDF]
, 1935 W. P. Roop
+8 more sources
A molecular portrait of microsatellite instability across multiple cancers
Nature Communications, 2016 Microsatellite instability (MSI) refers to the hypermutability of short repetitive sequences in the genome caused by impaired DNA mismatch repair. Although MSI has been studied for decades, large amounts of sequencing data now available allows us to ...
I. Cortés-Ciriano +4 more
semanticscholar +1 more source