Results 101 to 110 of about 3,048,905 (395)
Numerical Simulation on Damage and Failure Mechanism of Rock under Combined Multiple Strain Rates
Shock and Vibration, 2018 During underground hard-rock mining, the drilling and blasting method currently remains the most economical excavation method, and the rock may experience a multistrain-rate spectrum under quasi-static, dynamic, and rheological loading conditions and ...
Wancheng Zhu +4 more
doaj +1 more source
, 2009 For monopoles with nonvanishing Higgs potential it is shown that with respect to "Brandt-Neri-Coleman type" variations (a) the stability problem reduces to that of a pure gauge theory on the two-sphere (b) each topological sector admits one, and only one,
Horvathy, P. A. +2 more
core +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
Spatial-temporal evolution of the current filamentation instability [PDF]
, 2015 The spatial-temporal evolution of the purely transverse current filamentation instability is analyzed by deriving a single partial differential equation for the instability and obtaining the analytical solutions for the spatially and temporally growing ...
Fonseca, R. A. +4 more
core +2 more sources
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Pulsational Pair-instability Supernovae [PDF]
, 2016 The final evolution of stars in the mass range 70–140 M ⊙ is explored. Depending upon their mass loss history and rotation rates, these stars will end their lives as pulsational pair-instability supernovae (PPISN) producing a great variety of ...
S. Woosley
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Nature Communications, 2018 This Article contains errors in Fig. 3, Fig. 4 and Fig. 7, for which we apologize. In Fig. 3, panel ‘b’, the 0.5 hour time point after Ku55933 treatment images were inadvertently replaced with duplicates of the 3 hour time point after Ku55933 treatment ...
Jung-Hee Lee +11 more
doaj +1 more source
Screw instability of the magnetic field connecting a rotating black hole with its surrounding disk
, 2003 Screw instability of the magnetic field connecting a rotating black hole (BH) with its surrounding disk is discussed based on the model of the coexistence of the Blandford-Znajek (BZ) process and the magnetic coupling (MC) process (CEBZMC).
Blandford R. D. +7 more
core +1 more source
Molecular Oncology, EarlyView.This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci +6 more
wiley +1 more source