Results 41 to 50 of about 2,390,832 (281)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Disruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation

Experimental and Molecular Medicine
Wnt signaling is essential for cell growth and tumor formation and is abnormally activated in colorectal cancer (CRC), contributing to tumor progression; however, the specific role and regulatory mechanisms involved in tumor development remain unclear ...
Jeeho Kim, Young Jin Jeon, In-Youb Chang, Jung-Hee Lee, Ho Jin You   +4 more
doaj   +1 more source

A hybrid recognition model of microseismic signals for underground mining based on CNN and LSTM networks

Geomatics, Natural Hazards & Risk, 2021
Microseismic (MS) monitoring technology has been widely used to monitor ground pressure disasters. However, the underground mining environment is complex and contains many types of noise sources.
Yong Zhao, Haiyan Xu, Tianhong Yang, Shuhong Wang, Dongdong Sun   +4 more
doaj   +1 more source

Qualitative and quantitative analysis of stability and instability dynamics of positive lattice solitons

, 2008
We present a unified approach for qualitative and quantitative analysis of stability and instability dynamics of positive bright solitons in multi-dimensional focusing nonlinear media with a potential (lattice), which can be periodic, periodic with ...
B. Crosignani, B. Ilan, C. Pethick, C. Sulem, G. Fibich, M. I. Weinstein, M. I. Weinstein, M. P. Marder, M. Senechal, R. H. Goodman, T. Kupper, V. Konotop, Y. Kivshar, Y. Sivan   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Low density instability in a nuclear Fermi liquid drop

, 1998
The instability of a Fermi-liquid drop with respect to bulk density distortions is considered. It is shown that the presence of the surface strongly reduces the growth rate of the bulk instability of the finite Fermi-liquid drop because of the anomalous ...
A. A. Abrikosov, A. G. Magner, B. Jacquot, B. Jacquot, C. J. Pethick, C. J. Pethick, D. Kiderlen, G. Eckart, G. F. Bertsch, H. Heiselberg, H. Lamb, H. Müller, J. Konopka, J. R. Nix, M. Colonna, M. Colonna, M. Colonna, P. Ring, R. K. Bhaduri, S. Ayik, S. Shlomo, V. Baran, V. M. Kolomietz, V. M. Kolomietz, V. M. Kolomietz, V. M. Kolomietz, Y. M. Engel   +26 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Integrated simulation and monitoring to analyze failure mechanism of the anti-dip layered slope with soft and hard rock interbedding

International Journal of Mining Science and Technology, 2023
The significant difference between the mechanical properties of soft rock and hard rock results in the complexity of the failure mode of the anti-dip layered slope with soft and hard rock interbedding.
Jinduo Li, Yuan Gao, Tianhong Yang, Penghai Zhang, Yong Zhao, Wenxue Deng, Honglei Liu, Feiyue Liu   +7 more
doaj   +1 more source

Neutrino transport and hydrodynamic stability of rotating proto-neutron stars

, 2007
We consider stability of differentially rotating non-magnetic proto-neutron stars. When neutrino transport is efficient, the star can be subject to a diffusive instability that can occur even in the convectively stable region.
Urpin, V.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source