Results 41 to 50 of about 408,673 (331)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Analytical study on meshing performance of helical cylindrical gears with the coupling of tooth flank morphology and installation error

Journal of Advanced Mechanical Design, Systems, and Manufacturing
This paper investigates the coupling mechanism between installation errors of helical cylindrical gears and tooth flank modification methods on meshing performance.
Chengcheng LIANG, Yihao ZHANG, Longhua LIU, Ruijun LIU   +3 more
doaj   +1 more source

A Method for the Installation Measurement and Alignment of a Mirror Unit in the Solar Dish Concentrator

Applied Sciences, 2020
The mirror unit installation error of the solar parabolic dish concentrator can adversely affect its optical performance causing optical intercept losses and hot spots on the absorber surface, which in turn affect safety.
Jian Yan, Youduo Peng, Duzhong Nie
doaj   +1 more source

High-Speed Communications Over Polymer Optical Fibers for In-Building Cabling and Home Networking [PDF]

, 2010
This paper focuses on high-speed cabling using polymer optical fibers (POF) in home networking. In particular, we report about the results obtained in the POF-ALL European Project, which is relevant to the Sixth Framework Program, and after two years of ...
Abrate, S., Gaudino, Roberto, Nespola, A., Offenbeck, B., Weber, N., Zerna, C.   +5 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

JAMINAN PROTEKSI RADIASI DARI PESAWAT Co-60 DI INSTALASI RADIOTERAPI RSUD Dr. MOEWARDI [PDF]

, 2016
This study reported the radiation protection activity in Radiotherapy Installation of Dr. Moewardi Local General Hospital in January 2016. This activity was conducted by measuring and calculating computer simulation.
Rahmat, Asih Rahmini
core  

Experimental assessment of a helical coil heat exchanger operating at subcritical and supercritical conditions in a small-scale solar organic rankine cycle [PDF]

, 2017
In this study, the performance of a helical coil heat exchanger operating at subcritical and supercritical conditions is analysed. The counter-current heat exchanger was specially designed to operate at a maximal pressure and temperature of 42 bar and ...
Billiet, Marijn, De Paepe, Michel, Kaya, Alihan, Lazova, Marija, Lecompte, Steven, Manolakos, Dimitris   +5 more
core   +3 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source