Results 71 to 80 of about 1,904,166 (240)

Conciliando agência e contexto na dinâmica da mudança institucional

Cadernos EBAPE.BR
ResumoEste ensaio apresenta estrutura analítica que busca conciliar elementos da agência e do contexto na análise de processos de mudança institucional.
Diego Maganhotto Coraiola, Márcio Jacometti, Marystela Assis Baratter, Sandro Aparecido Gonçalves   +3 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Community engagement and financial arrangements: Navigating institutional change. [PDF]

J Clin Transl Sci, 2023
Sprague Martinez L, Howard RC, Schotland M, Lobb R, Battaglia T, Stone S, Auerswald C, Ozer E.   +7 more
europepmc   +1 more source

Paradigm Change/ Institute Change

, 2014
We are in the midst of paradigm change, brought on by initiatives like biological systems theory, post-structuralism, James Gibson’s theory of affordances,1 and neuroplasticity.Top-down or prime-mover models of change have given way to principles of creative interactivity and causal pari-ty, in which ...
L.O. Aranye Fradenburg, Eileen A. Joy
openaire   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Rights in the Time of Populism: Land and Institutional Change Amid the Reemergence of Right-Wing Authoritarianism in Colombia

Land, 2019
In Colombia, right-wing leadership returned to power after winning the presidential elections in 2018 in a campaign in which they opposed the previous government, primarily because of the negotiations and peacemaking with the FARC-EP (Fuerzas Armadas ...
Sergio Coronado
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Educational Policy Development as a Leadership Experience: Inclusive Institutional Change. [PDF]

Med Sci Educ, 2023
Cheema A, Morris L, Suresh A, Carhart B, Thomson C, Synan L, Sorensen MJ, Chimienti SN.   +7 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Contemporary Research on Agency in Education: A Systematization of Key Concepts and Developments

Вопросы образования
The task of developing individual "agency" (autonomy, proactivity, initiative, etc.), in education is widely discussed in scientific and practical circles.
Pavel S. Sorokin, Timofey D. Redko
doaj   +1 more source