Results 71 to 80 of about 20,299,212 (382)

Contextualising the context in policy entrepreneurship and institutional change

, 2017
While there is a considerable literature concerning policy entrepreneurship and institutional isomorphism, significantly less literature has emerged addressing the impact of context on policy and institutional entrepreneurship and of the interactions ...
Caner Bakir, D. Jarvis
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Assessing the long- and short-run effects of climate change and institutional quality on economic growth in Somalia [PDF]

, 2023
Abdimalik Ali Warsame, Ibrahim Abdukadir Sheik-Ali, Hassan Abdikadir Hussein, Galad Mohamed Barre   +3 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Rights in the Time of Populism: Land and Institutional Change Amid the Reemergence of Right-Wing Authoritarianism in Colombia

Land, 2019
In Colombia, right-wing leadership returned to power after winning the presidential elections in 2018 in a campaign in which they opposed the previous government, primarily because of the negotiations and peacemaking with the FARC-EP (Fuerzas Armadas ...
Sergio Coronado
doaj   +1 more source

Institutional change and Institutional Integration in France: Health Regional Agencies what consequences for the development of integrated services delivery? [PDF]

International Journal of Integrated Care, 2012
Hélène Trouvé, Olivier Saint-Jean, Dominique Somme   +2 more
doaj   +1 more source

Mechanisms of Endogenous Institutional Change [PDF]

This paper proposes an analytical-cum-conceptual framework for understanding the nature of institutions as well as their changes. In doing so, it attempts to achieve two things: First, it proposes a way to reconcile an equilibrium (endogenous) view of ...
Masahiko Aoki
core  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

The effect of political leaders on economic growth through institutional change

Romanian Economic Journal, 2015
The article summarizes the influence of political leaders on institutions which, according to institutional economics, directly influences economic growth.
Dóra Zolcsák
doaj  

Reimagining a path from institutional willingness to readiness: ecosystem variables that promote or impede sustainable transformation in higher education

Frontiers in Education
Many colleges and universities purport agendas involving strategies centered on the readiness to diversify the faculty, staff, and student bodies, modernize curricula, and promote innovation in research and discovery, among other advancements.
Joseph A. Whittaker, Beronda L. Montgomery   +1 more
doaj   +1 more source