Results 81 to 90 of about 297,035 (311)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

How Does Transformational Leadership Improve Instructional Practices? Examining the Mediation Role of Teachers’ Change-Oriented Organizational Citizenship Behavior and the Moderating Role of Organizational Appreciation

SAGE Open
Current research has shown that transformational leadership improves instructional practice, particularly by creating an environment that promotes educators and fosters a sense of belonging to improve teaching and learning efficacy.
Mariam Al Hammadi, Mumin Dayan, Mehmet Sukru Bellibas, Wondwesen Tafesse, Cintia Kulzer Sacilotto   +4 more
doaj   +1 more source

Exploring Instructional Leadership as a Praxis in Schools [PDF]

Social Sciences and Education Research Review
The importance of instructional leadership in promoting school growth and renewal is significant; however, it has received limited research attention and is not fully understood.
Victor J. Pitsoe, Mmalefikane Sylvia Sepeng   +1 more
doaj   +1 more source

The impact of principal's instructional leadership behavior on PPSMI teachers' teaching practices [PDF]

, 2007
The critical role for all principals is that of being an instructional leader. Leadership in instructional matters should emerge freely from both the principal and teachers.
Abdul Wahab, Mahidah, Abdullah, Abdul Ghani Kanesan   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The ideology of instructional leadership among principals on student academic achievement [PDF]

, 2016
Malaysian education system has come under public scrutiny and debate, their concern regarding not only the system but also the teachers and administrators to adequately prepared young Malaysian for the 21st century. The purpose of the study is to explore
Ali Bashah, Mohd Helmi, Basri, Ramli, Fooi, Foo Say, Lope Pihie, Zaidatol Akmaliah, Mohamad Yasin, Murni, Zainal, Hasny @ Yanti   +5 more
core  

Instructional Leadership at Schools

, 2023
The main goal of learning leadership is to provide excellent service to all students so that they are able to develop their potential basic qualities and instrumental qualities to face a future that is unknown and full of very turbulent challenges. Basic qualities include the quality of the mind, heart, and physical power.
openaire   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

INSTRUCTIONAL LEADERSHIP: THE ROLE OF HEADS OF SCHOOLS IN MANAGING THE INSTRUCTIONAL PROGRAMME

International Journal of Educational Leadership and Management, 2016
Scholars and practitioners agree that instructional leadership (IL) can be one of the most useful tools for creating an effective teaching and learning environment.
Aaron Mkanga Manaseh
doaj   +1 more source

Instructional Materials and Implementation of Next Generation Science Standards: Demand, Supply, and Strategic Opportunities [PDF]

, 2017
Next Generation Science Standards (NGSS) are in demand, but the supply of high quality K-12 instructional materials in science is lacking. This disconnect comes at a critical time in the implementation of new science standards, which are now influencing ...
Christine Chopyak, Rodger Bybee
core