Results 71 to 80 of about 297,035 (311)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Exploring How Change Leadership Influences Instructional Leadership Effects on School Culture and Teachers’ Teaching Performance in Pesantren Education Settings in Indonesia: A Moderated-Mediation Analysis

Journal on Efficiency and Responsibility in Education and Science
As an instructional leader, the principal is instrumental in facilitating the adjustment to the more advanced school environment by supporting teachers and students in their endeavors.
Desi Eri Kusumaningrum, Imam Gunawan, Raden Bambang Sumarsono, Retnani Latifah   +3 more
doaj   +1 more source

Kompetensi Kerja Guru, Kepemimpinan Pembelajaran Dan Kinerja Mengajar Guru Tk Kota Bandung [PDF]

, 2015
This research is motivated by not maximal performance of teachers and principals of kindergartens in the city of Bandung. To achieve good performance necessary competence and leadership of teacher learning (instructional leadership) principals of ...
Faridah, I. (Iis), Kurniady, D. A. (Dedy)   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Perceptions and practices of principals: examining instructional leadership for curriculum reform

Frontiers in Education
A theoretical and empirical grounded explanation is constructed on how primary school principals perceive and enact instructional leadership during curriculum reform.
Moeketsi David Ralebese, Loyiso Currell Jita, Olalekan Taofeek Badmus   +2 more
doaj   +1 more source

Improving School Leadership: The Connection of Transformational Leadership and Psychological Well-Being of the Followers [PDF]

, 2018
In this current era of public school accountability in the United States, the passage of No Child Left Behind resulted in dramatic changes for public school districts (U.S. Department of Education, 2001).
Bryant, Pamela, Butcher, Jennifer T., O\u27Connor, Johnny   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

AN EVALUATION OF THE ROLE OF INSTRUCTIONAL LEADERSHIP ON THE PERFORMANCE OF SCHOOLS IN ZIMBABWE [PDF]

Studia Universitatis Babeş-Bolyai. Psychologia-Paedagogia, 2016
. The purpose of this research was to investigate the extent to which instructional leadership is contributing to the performance of schools in Zimbabwe.
MAXWELL SANDADA, MWANYARA MAKAMANI
doaj  

Female Middle School Principals\u27 Voices: Implications for School Leadership Preparation [PDF]

, 2009
This study was an attempt to add the voices of women to the discourse of sch.ool leadership. It focused on the nature of the middle school leadership experiences of three female middle school principals, their social interactions based on gen- der role ...
High, Cynthia, Jones, Cathy, Ovando, Martha N.   +2 more
core   +1 more source