Results 81 to 90 of about 4,628,960 (295)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Announcement, Instructional Design Strategies Instructional Materials Training, October 16, 2014

open access: yes, 2014
Announcement for a training on designing instructional materials for ...
University of South Florida St. Petersburg. Nelson Poynter Memorial Library. Online Learning and Instructional Technology Services   +1 more
core  

The nature and quality of the mathematical connections teachers make

open access: yesPythagoras, 2012
Current reforms in mathematics education emphasise the need for pedagogy because it offers learners opportunities to develop their proficiency with complex high-level cognitive processes.
Michael K. Mhlolo   +2 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Exploring Complex Concepts Through Storytelling: A Synchronous Online Health Policy Course Case Study and Recommendations for Implementing Across Disciplines

open access: yesOpen Praxis, 2022
Educational experts advocate for storytelling’s community building aspects; it is also a valuable tool for deepening students’ cognitive engagement.
Corrie Whitmore, Kathryn Schild
doaj  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Instructional Strategies In Math

open access: yes
Marginalized students face a range of gaps in experience, highlighting the importance of better understanding these students’ opportunities to learn.
Kelley Durkin   +2 more
core   +1 more source

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