Results 31 to 40 of about 28,623 (152)

Effect of high glucose concentration on the synthesis of monocyte chemoattractant protein-1 in human peritoneal mesothelial cells: Involvement of protein kinase C [PDF]

, 2001
Human peritoneal mesothelial cells (HMC) contribute to the activation and control of inflammatory processes in the peritoneum by their potential to produce various inflammatory mediators.
Haslinger, Bettina, Lederer, Stephan R., Mandl-Weber, Sonja, Sellmayer, Alois, Sitter, Thomas   +4 more
core   +1 more source

Transparent Transfer‐Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices

Advanced Science, EarlyView.
A transfer‐free fabrication method enables multilayer graphene microelectrodes as small as 10 µm, eliminating reliability issues of manual graphene transfer. These electrodes record neural activity in brain slices with exceptional signal‐to‐noise ratios (up to 25–40 dB) while maintaining optical transparency for multimodal applications.
Nerea de Alvarez de Eulate, Christos Pavlou, Gonzalo León González, María Camarena Pérez, Lukas Holzapfel, Zhenyu Gao, Sten Vollebregt, Vasiliki Giagka   +7 more
wiley   +1 more source

Intelligent Products: Shifting the Production Control Logic in Construction (With Lean and BIM) [PDF]

, 2015
Production management and control in construction has not been addressed/updated ever since the introduction of Critical Path Method and the Last Planner® system.
Dave, Bhargav, Främling, Kary, Holmström, Jan, Koskela, Lauri, Kubler, Silvain, Peltokorp, Antti, Pikas, Ergo, Singh, Vishal   +7 more
core  

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

, 2019
Here, using an integrative experimental and computational approach, Imle et al. show how cell motility and density affect HIV cell-associated transmission in a three-dimensional tissue-like culture system of CD4+ T cells and collagen, and how different ...
Ales, J., Carrillo-Bustamante, P., Fackler, O., Fehr, J., Godinez, W., Graw, F., Hamprecht, F., Imle, A., Kumberger, P., Müller, B., Ritter, C., Rohr, K., Schmidt, P., Schnellbächer, N., Schwarz, U.   +14 more
core   +2 more sources

Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]

, 2018
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta, Bianchi, Massimiliano G., Bussolati, Ovidio, Chiu, Martina, Ciociola, Tecla, Lagrasta, Costanza A M, Ottaviani, Laura, Tardito, Saverio, Taurino, Giuseppe   +8 more
core   +2 more sources

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Navigating across individual and deliberative values: A dual Q‐method approach to elicit diverse values in grassland restoration

People and Nature, EarlyView.
Abstract The current ‘UN Decade on Restoration’ calls for collaboration between scientists and practitioners to formulate guidelines for ecosystem restoration, within which transdisciplinary approaches are imperative to rethink the diverse values associated with nature, paving the way for sustainable ecosystem restoration.
Miguel A. Cebrián‐Piqueras, Konrad Gray, Lukas Kuhn, Jacqueline Loos, Ioana A. Pătru‐Dușe, Maraja Riechers, Vicky Temperton, Berta Martín‐López   +7 more
wiley   +1 more source

Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis. [PDF]

, 2015
BackgroundIn multiple sclerosis (MS) and its widely used animal model, experimental autoimmune encephalomyelitis (EAE), autoreactive T cells contribute importantly to central nervous system (CNS) tissue damage and disease progression. Promoting apoptosis
Chen, Yingyu, Deng, Wenbin, Liu, Wenwei, Xiao, Juan   +3 more
core   +2 more sources

2D van der Waals System Integrated with Targeting Radio‐Diagnostic and Imaging Functions

Small, EarlyView.
Layered double hydroxide (LDH) nanoplates were engineered for tumor‐targeted imaging and therapy. By exploiting folate receptor (FR) expression levels, the system achieves selective tumor accumulation and high‐resolution dual PET/fluorescence (PET/FL) imaging.
Sairan Eom, Jae Hun Ahn, Jung Yung Kim, Kyo Chul Lee, Yong Jin Lee, Sanoj Rejinold N, Jin‐Ho Choy   +6 more
wiley   +1 more source