Results 91 to 100 of about 434,866 (360)

Association of body mass index with disability in activities of daily living in older adults: a systematic review of the literature based on longitudinal data

BMC Public Health
Background The influence of Body Mass Index (BMI) on the functional capacity for daily activities in older adults is a significant concern. Our study is designed to delineate the longitudinal relationship between BMI and the ability of daily living ...
Wang Lingying, Zhu Hong, Chen Hongxiu, Hu Ziyi, Feng Mei, Tang Menglin, Hu Xiuying   +6 more
doaj   +1 more source

A Profile of Frail Older Americans and Their Caregivers [PDF]

, 2006
Provides a profile of older Americans and their caregivers, focusing on people age 65 and older who are not in nursing homes, and those with severe disabilities.
Joshua M. Wiener, Richard W. Johnson
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The bidirectional relationship between activities of daily living and frailty during short-and long-term follow-up period among the middle-aged and older population: findings from the Chinese nationwide cohort study

Frontiers in Public Health
ObjectiveFrailty and activities of daily living (ADL) disability are common conditions among older population. Studies on the bidirectional relationship between frailty and ADL are limited.
Xiaoping Li, Xiaoguang Li, Lu Sun, Liu Yang, Congzhi Wang, Ting Yuan, Yunxiao Lei, Jing Li, Mingming Liu, Dongmei Zhang, Ying Hua, Haiyang Liu, Lin Zhang   +12 more
doaj   +1 more source

The IMMED Project: Wearable Video Monitoring of People with Age Dementia [PDF]

, 2010
International audienceIn this paper, we describe a new application for multimedia indexing, using a system that monitors the instrumental activities of daily living to assess the cognitive decline caused by dementia.
André-Obrecht, Régine, Benois-Pineau, Jenny, Dartigues, Jean-François, Dovgalecs, Vladislavs, El Khoury, Elie, Gaëstel, Yann, Joly, Philippe, Karaman, Svebor, Mégret, Rémi, Pinquier, Julien, Wannous, Hazem   +10 more
core   +1 more source

Digital Endpoints for Assessing Instrumental Activities of Daily Living in Mild Cognitive Impairment: A Systematic Review [PDF]

, 2023
Lauren Lawson, Ríona Mc Ardle, Sarah Wilson, Emily Beswick, Radin Karimi, Sarah P. Slight   +5 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Performance-based Tools for Assessing Functional Performance in Individuals with Mild Cognitive Impairment

Open Journal of Occupational Therapy, 2015
Background: It is now recognized that individuals with mild cognitive impairment (MCI) face subtle functional declines that can compromise performance in everyday tasks.
Patrícia Belchior, Melanie Holmes, Nathalie Bier, Carolina Bottari, Barbara Mazer, Alexandra Robert, Navaldeep Kaur   +6 more
doaj   +1 more source

A comparison of laboratory, clinical and self-report measures of prospective memory in healthy adults and individuals with brain injury [PDF]

, 2017
Individuals with traumatic brain injury (TBI) have demonstrated deficits in prospective memory (PM) functioning when compared to healthy adults.
Antonia Pereira, Beck A., Beck A. T., David H. K. Shum, Dobbs A. R., Ellis J., Ellis J. A., Ginger Mills, Judi Ellis, Neulinger K., Raskin S., Sarah A. Raskin, Sherer M., Wilson B. A., Woods S. P.   +14 more
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source