Results 71 to 80 of about 393,540 (338)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Caregiving and elderly health in Mexico [PDF]

, 2012
Using the National Mexican Health and Aging Study panel dataset, the authors estimate the effect of having informal care on the probability of dying and on the change in elderly health over a two-year period. Three measures of functional health were used:
Angeles, G., Mroz, T., Piras, C., Tran, N., Trujillo, A.J.   +4 more
core   +2 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Digital exclusion and functional dependence in older people: Findings from five longitudinal cohort studiesResearch in context

EClinicalMedicine, 2022
Summary: Background: Older people are more likely to be excluded from the digital world, and this has been linked to poor health outcomes. The extent and direction of the influence of digital exclusion on functional dependency is, however, not well ...
Xinran Lu, Yao Yao, Yinzi Jin
doaj  

Assessment of functional capacity in patients attending geriatrics outpatient department at Civil Hospital, Ahmedabad

CHRISMED Journal of Health and Research, 2016
Aims: To access the quality of life in terms of functional capacity and to estimate the prevalence of depression among geriatric patients. Settings and Design: A hospital-based study was conducted in Civil Hospital, Ahmedabad between July and September ...
Neeta Mathur
doaj   +1 more source

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review [PDF]

, 2015
Introduction: There is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI).
Bullock, Roger, Connelly, Peter J., Damian, Marinella, Dubois, Bruno, Eriksdotter, Maria, Ewers, Michael, Frölich, Lutz, Graessel, Elmar, Hausner, Lucrezia, Jekel, Katrin, Kramberger, Milica G., Law, Emma, Mecocci, Patrizia, Molinuevo, José L., Nygård, Louise, Olde-Rikkert, Marcel GM, Orgogozo, Jean-Marc, Pasquier, Florence, Peres, Karine, Salmon, Eric, Sikkes, Sietske AM, Sobow, Tomasz, Spiegel, René, Tsolaki, Magda, Wattmo, Carina, Winblad, Bengt   +25 more
core   +3 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

The Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument [PDF]

Movement Disorders Clinical Practice, 2019
ABSTRACTBackgroundIndividuals with Parkinson's disease often experience periods of off time when their motor symptoms are poorly controlled, significantly impacting their lives.ObjectivesTo identify the consequences of motor fluctuations on day‐to‐day activities and areas of unmet treatment priority among individuals with moderate to advanced Parkinson'
Emuella Flood, David Gray, Daniela E. Myers, Jacob Devine, Linda S. Deal   +4 more
openaire   +3 more sources