Effects of Adjusting for Instrumental Variables on the Bias and Precision of Propensity Score Weighted Estimators: Analysis Under Complete, Near, and No Positivity Violations. [PDF]
Clin Epidemiol, 2023 Choi BY, Brookhart MA.
europepmc +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Identification and estimation by penalization in nonparametric instrumental regression [PDF]
The nonparametric estimation of a regression function x from conditional moment restrictions involving instrumental variables is considered. The rate of convergence of penalized estimators is studied in the case where x is not identified from the ...
FLORENS, Jean-Pierre +2 more
core
The UK BiLEVE and Mendelian randomisation: using multivariable instrumental variables to address "damned if you, damned if you don't" adjustment problems. [PDF]
BMC Res Notes, 2023 Woolf B, Gill D, Sallis H, Munafò MR.
europepmc +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Symmetrically normalized instrumental-variable estimation using panel data. [PDF]
In this paper we discuss the estimation of panel data models with sequential moment restrictions using symmetrically normalized GMM estimators. These estimators are asymptotically equivalent to standard GMM but are invariant to normalization and tend to ...
Arrellano, Manuel +1 more
core
Integrating Cross-Lagged Panel Models with Instrumental Variables to Extend the Temporal Generalizability of Causal Inference. [PDF]
Multivariate Behav Res, 2023 Singh M, Dolan CV, Neale MC.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Instrumental Regression in Partially Linear Models [PDF]
We consider the semiparametric regression Xtβ+φ(Z) where β and φ(·) are unknown slope coefficient vector and function, and where the variables (X,Z) are endogeneous.
Van Bellegem, Sébastien +2 more
core
MR-DoC2: Bidirectional Causal Modeling with Instrumental Variables and Data from Relatives. [PDF]
Behav Genet, 2023 Castro-de-Araujo LFS +6 more
europepmc +1 more source