Frameworks for estimating causal effects in observational settings: comparing confounder adjustment and instrumental variables. [PDF]
BMC Med Res Methodol, 2023 Zawadzki RS +3 more
europepmc +1 more source
Instrumental variables estimation with flexible distribution [PDF]
Instrumental variables are often associated with low estimator precision. This paper explores efficiency gains which might be achievable using moment conditions which are nonlinear in the disturbances and are based on flexible parametric families for ...
Christian Hansen +2 more
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
systemfit: A Package for Estimating Systems of Simultaneous Equations in R
Journal of Statistical Software, 2007 Many statistical analyses (e.g., in econometrics, biostatistics and experimental design) are based on models containing systems of structurally related equations.
Arne Henningsen, Jeff D. Hamann
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The UK BiLEVE and Mendelian randomisation: using multivariable instrumental variables to address "damned if you, damned if you don't" adjustment problems. [PDF]
BMC Res Notes, 2023 Woolf B, Gill D, Sallis H, Munafò MR.
europepmc +1 more source
Instrumental Variables and GMM: Estimation and Testing
, 2003 Christopher F. Baum +2 more
semanticscholar +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Integrating Cross-Lagged Panel Models with Instrumental Variables to Extend the Temporal Generalizability of Causal Inference. [PDF]
Multivariate Behav Res, 2023 Singh M, Dolan CV, Neale MC.
europepmc +1 more source
An instrumental variable model of multiple discrete choice [PDF]
This paper studies identification of latent utility functions in multiple discrete choice models in which there may be endogenous explanatory variables, that is explanatory variables that are not restricted to be distributed independently of the ...
Adam Rosen +2 more
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