Results 51 to 60 of about 23,904 (284)

Living for the weekend: youth identities in northeast England [PDF]

open access: yes, 2009
Consumption and consumerism are now accepted as key contexts for the construction of youth identities in de-industrialized Britain. This article uses empirical evidence from interviews with young people to suggest that claims of `new community' are ...
Badiou, A.   +54 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Anti-Nirvana: crime, culture and instrumentalism in the age of insecurity [PDF]

open access: yes, 2005
‘Anti-Nirvana’ explores the relationship between consumer culture, media and criminal motivations. It has appeared consistently on the list of the top-ten most-read articles in this award-winning international journal, and it mounts a serious neo ...
Baudrillard, J.   +43 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pragma-Dialetics Epistemologized: Reply to Lumer

open access: yesInformal Logic, 2012
I would like to thank Christoph Lumer for his illuminating comments on my paper “The question of truth” published in this journal (Botting 2010) and would like to exercise my right of reply on a few of the issues that he raises.
David Botting
doaj   +3 more sources

Conventionalism and Theory of Meaning

open access: yesFilosofie Dnes, 2016
What is conventionalism in philosophy of science? Basically, it is a thesis about empirical underdetermination. According to Conventionalists, there is “a slack” between our theories and experience that is to be “lined” with conventions.
Jindřich Černý
doaj   +1 more source

Crossing the symbolic threshold: a critical review of Terrence Deacon's The Symbolic Species [PDF]

open access: yes, 2002
Terrence Deacon's views about the origin of language are based on a particular notion of a symbol. While the notion is derived from Peirce's semiotics, it diverges from that source and needs to be investigated on its own terms in order to evaluate the ...
Lumsden, David
core   +2 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Realism, Instrumentalism, and Scientific Symbiosis: Psychological Theory as a search for truth and the discovery of solutions [PDF]

open access: yes, 2004
Scientific realism holds that scientific theories are approximations of universal truths about reality, whereas scientific instrumentalism posits that scientific theories are intellectual structures that provide adequate predictions of what is observed ...
Ayer   +29 more
core   +2 more sources

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