Results 21 to 30 of about 536,079 (263)

Insulin-like growth factor-I and its binding proteins in healthy mothers and their newborns [PDF]

Einstein (São Paulo), 2004
Objective: To determine serum levels of insulin-like growth factor-I, free insulin-like growth factor-I and its binding proteins in maternalserum and in cord blood of two groups of newborns with differentbirth weights.
Rosanna Velleca Lima, Daniel Giannella Neto, Conceição Aparecida de Mattos Segre, Saul Goldenberg   +3 more
doaj  

Revisiting the IGF-1R as a breast cancer target

npj Precision Oncology, 2017
The type I insulin-like growth factor-1 receptor is a well-described target in breast cancer and multiple clinical trials examining insulin-like growth factor-1 receptor have been completed.
Roudy Chiminch Ekyalongo, Douglas Yee
doaj   +1 more source

Human conditions of insulin-like growth factor-I (IGF-I) deficiency

Journal of Translational Medicine, 2012
Insulin-like growth factor I (IGF-I) is a polypeptide hormone produced mainly by the liver in response to the endocrine GH stimulus, but it is also secreted by multiple tissues for autocrine/paracrine purposes. IGF-I is partly responsible for systemic GH
Puche Juan E, Castilla-Cortázar Inma
doaj   +1 more source

The insulin-like growth factor I receptor regulates glucose transport by astrocytes [PDF]

, 2016
Previous findings indicate that reducing brain insulin-like growth factor I receptor (IGF-IR) activity promotes ample neuroprotection. We now examined a possible action of IGF-IR on brain glucose transport to explain its wide protective activity, as ...
Allaman, Barnes, Barros, Barros, Biondi, Booth, Boucher, Bunn, C, Carro, Chuquet, Cohen, Cohen, Dringen, Dull, Fernandez, Fernandez, Gazit, Gontier, Gonzalez, Hamai, Jakoby, Kenyon, Koshy, Kum, Kuntner, L, La Joie, Ligensa, Liu, Loaiza, Lopez-Otin, M, Magalhaes Filho, Masters, Mathiisen, Matsunaga, Mergenthaler, Morgello, Muhic, Munive, Nimmerjahn, Nishijima, Perez-Alvarez, Pfaffl, Porras, Roy, Vilchez, Wieman, Winkler   +49 more
core   +1 more source

Growth Hormone Receptor Gene Expression Increase Reflects Nutritional Status Improvement in Patients Affected by Crohn's Disease

Frontiers in Pediatrics, 2018
Background: We proposed to verify the role of growth hormone receptor gene expression in growth failure of children with Crohn's disease (CD).Methods: We measured serum levels of growth hormone binding protein (GHBP) and insulin-like growth factor-I (IGF-
Sara Pagani, Elena Bozzola, Caterina Strisciuglio, Cristina Meazza, Erasmo Miele, M. Malamisura, Paola De Angelis, Mauro Bozzola   +7 more
doaj   +1 more source

Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain [PDF]

, 2016
Insulin and insulin-like growth factors I and II are closely related protein hormones. Their distinct evolution has resulted in different yet overlapping biological functions with insulin becoming a key regulator of metabolism, whereas insulin-like ...
Collinsová, Michaela, Crump, Matthew P, Fábry, Milan, Hexnerová, Rozálie, Jiráček, Jiří, Kedrová, Kateřina, Křížková, Květoslava, Sieglová, Irena, Srb, Pavel, Tošner, Zdeněk, Ullrichová, Pavlína, Veverka, Václav, Williams, Christopher, Žáková, Lenka   +13 more
core   +2 more sources

Type I Insulin-like Growth Factor Receptor Induces Pulmonary Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2009
Despite the type I insulin-like growth factor receptor (IGF-IR) being highly expressed in more than 80% of human lung tumors, a transgenic model of IGF-IR overexpression in the lung has not been created.
Nicolle M. Linnerth, Megan D. Siwicky, Craig I. Campbell, Katrina L.M. Watson, James J. Petrik, Jeffrey A. Whitsett, Roger A. Moorehead   +6 more
doaj   +1 more source

Obesity and breast cancer in premenopausal women: Current evidence and future perspectives [PDF]

, 2018
There is raising evidence reporting an increased incidence of breast cancer over the past decades. Every year approximately 1.4 million new cases of breast cancer are diagnosed worldwide, with a mortality rate of approximately 450,000/year.
Barrea, Luigi, Colao, Annamaria, Laudisio, Daniela, Muscogiuri, Giovanna, Savastano, Silvia   +4 more
core   +1 more source

Insulin-like Growth Factor-I in Muscle Metabolism and Myotherapies

Neurobiology of Disease, 2001
The critical anabolic and trophic role of signaling by insulin-like growth factors (IGF) I and II via the type-I IGF receptor (IGF-IR) is reviewed throughout the life of skeletal myocytes.
J.Robinson Singleton, Eva L. Feldman
doaj   +1 more source

Characteristics and treatment outcomes of micromegaly – acromegaly with apparently normal basal GH: A retrospective study and literature review

Endocrine Regulations, 2022
Objective. Micromegaly describes a subgroup of patients with clinically evident acromegaly and elevated insulin-like growth factor I (IGF-I) with apparently normal basal growth hormone (bGH) and often a glucose-suppressed growth hormone (GH) of
Inacio Isabel, Fonseca Liliana, Amado Ana, Benido Vania, Ribeiro Isabel, Dores Jorge, Amaral Claudia, Cardoso Maria Helena   +7 more
doaj   +1 more source