Results 71 to 80 of about 113,369,369 (332)

Effect of Iron Deficiency Anemia on IGF-1 Level Among Sample of Children

Advanced Medical Journal, 2023
Background and objectives:Iron-deficiency anemia is a worldwide nutritional problem and an important public health problem especially in developing countries.
Kani Rast Noori, Abbas Abdulkadir Rabaty   +1 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Regulation of cardiac autophagy by insulin‐like growth factor 1 [PDF]

IUBMB Life, 2013
Insulin‐like growth factor‐1 (IGF‐1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF‐1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal‐regulated kinase (ERK), and phospholipase C (PLC)/inositol 1,4,5 ...
Troncoso, Rodrigo, Díaz Elizondo, Jessica, Espinoza, Sandra P., Navarro Márquez, Mario F., Oyarzún, Alejandra P., Riquelme, Jaime A., García Carvajal, Ivonne, Díaz Araya, Guillermo, García Nannig, Lorena, Hill, Joseph A., Lavandero González, Sergio   +10 more
openaire   +7 more sources

Insulin-Like Growth Factor-1 and Selected Insulin-Like Growth Factor Binding Protein Concentrations during an Ultramarathon Sled Dog Race

The Scientific World Journal, 2016
The objective of this study was to investigate the effects of running a 1000-mile (1600 km) endurance sled dog race on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins 1 and 3 (IGFBP-1 and IGFBP-3).
Matthew W. Brunke, Christopher W. Frye, Corri B. Levine, Cristina Hansen, Joseph J. Wakshlag   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Weber, Matthias M., Fottner, Christian, Simmler, Pia, Engelhardt, Dieter, M. M. Weber   +4 more
core   +2 more sources

Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2005
Abstract Insulin-like growth factors (IGFs) play key roles in cell proliferation and apoptosis. Whereas relatively stable within individuals, IGFs vary substantially between individuals, and a large component of this variation may be determined by genetic factors.
Libby M, Morimoto, Polly A, Newcomb, Emily, White, Jeannette, Bigler, John D, Potter   +4 more
openaire   +2 more sources

Insulin-like growth factor 1 stimulates the angiogenic activity of adipose tissue–derived microvascular fragments

Journal of Tissue Engineering, 2019
Angiogenesis in adipose tissue is promoted by insulin-like growth factor 1 signaling. We analyzed whether this regulatory mechanism also improves the angiogenic activity of adipose tissue–derived microvascular fragments.
Matthias W Laschke, Elena Kontaxi, Claudia Scheuer, Alexander Heß, Philipp Karschnia, Michael D Menger   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

IGF-I receptor phosphorylation is impaired in cathepsin X-deficient prostate cancer cells [PDF]

, 2012
The cysteine-type peptidase cathepsin X is highly upregulated in several cancers and presumably promotes tumor invasion through bypassing cellular senescence. Here, we present first evidence that the underlying mechanism may involve the regulation of the
Kraus, Steffen, Bunsen, Thea, Fruth, Maximilian, Nägler, Dorit K.   +3 more
core   +1 more source