Results 51 to 60 of about 39,607,185 (297)

Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]

, 1995
Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Weber, Matthias M., Fottner, Christian, Simmler, Pia, Engelhardt, Dieter, M. M. Weber   +4 more
core   +2 more sources

Risk prognosis correlation of insulin-like growth factor binding protein-3 and insulin-like growth factor-1 in uterine fibroids [PDF]

Journal of Medical Biochemistry
Background: To explore the relationships between the levels of serum insulin-like growth factor binding protein-3 (IGFBP-3) and insulin-like growth factor 1 (IGF-1) and immune factors, as well as the prognosis of patients with uterine fibroids.
Lin Tingting, Qian Keke, Chen Yanping, Li Mengshu, Zhang Zhang   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Effect of Iron Deficiency Anemia on IGF-1 Level Among Sample of Children

Advanced Medical Journal, 2023
Background and objectives:Iron-deficiency anemia is a worldwide nutritional problem and an important public health problem especially in developing countries.
Kani Rast Noori, Abbas Abdulkadir Rabaty   +1 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Identification of BRCA1 As a Potential Biomarker for Insulin-Like Growth Factor-1 Receptor Targeted Therapy in Breast Cancer

Frontiers in Endocrinology, 2017
The insulin-like growth factor-1 receptor (IGF1R) emerged in recent years as a promising therapeutic target in oncology. Identification of potential biomarkers capable of predicting response to IGF1R-targeted therapy is of cardinal importance.
Tali Cohen-Sinai, Tali Cohen-Sinai, Zoya Cohen, Haim Werner, Haim Werner, Raanan Berger   +5 more
doaj   +1 more source

Regulation of cardiac autophagy by insulin‐like growth factor 1 [PDF]

IUBMB Life, 2013
Insulin‐like growth factor‐1 (IGF‐1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF‐1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal‐regulated kinase (ERK), and phospholipase C (PLC)/inositol 1,4,5 ...
Troncoso, Rodrigo, Díaz Elizondo, Jessica, Espinoza, Sandra P., Navarro Márquez, Mario F., Oyarzún, Alejandra P., Riquelme, Jaime A., García Carvajal, Ivonne, Díaz Araya, Guillermo, García Nannig, Lorena, Hill, Joseph A., Lavandero González, Sergio   +10 more
openaire   +7 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Insulin-Like Growth Factor-1 and Selected Insulin-Like Growth Factor Binding Protein Concentrations during an Ultramarathon Sled Dog Race

The Scientific World Journal, 2016
The objective of this study was to investigate the effects of running a 1000-mile (1600 km) endurance sled dog race on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins 1 and 3 (IGFBP-1 and IGFBP-3).
Matthew W. Brunke, Christopher W. Frye, Corri B. Levine, Cristina Hansen, Joseph J. Wakshlag   +4 more
doaj   +1 more source

Variation in Plasma Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3: Genetic Factors [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2005
Abstract Insulin-like growth factors (IGFs) play key roles in cell proliferation and apoptosis. Whereas relatively stable within individuals, IGFs vary substantially between individuals, and a large component of this variation may be determined by genetic factors.
Libby M, Morimoto, Polly A, Newcomb, Emily, White, Jeannette, Bigler, John D, Potter   +4 more
openaire   +2 more sources