Results 31 to 40 of about 113,369,369 (332)

Changes in Insulin-like Growth Factor-1 Level in Patients with Sepsis and Septic Shock [PDF]

Korean Journal of Critical Care Medicine, 2016
Background Despite many ongoing, prospective studies on the topic, sepsis still remains one of the main causes of death in hospital. The hormone insulin-like growth factor 1 (IGF-1) has a similar molecular structure to that of insulin.
Sang Hoon Lee, Byung Hoon Park, Joo Han Song, Song Yee Kim, Kyung Soo Chung, Eun Young Kim, Ji Ye Jung, Young Sam Kim, Se Kyu Kim, Joon Chang, Moo Suk Park   +10 more
doaj   +1 more source

Insulin-like Growth Factor 1 Signaling in Mammalian Hearing [PDF]

Genes, 2021
Insulin-like growth factor 1 (IGF-1) is a peptide hormone belonging to the insulin family of proteins. Almost all of the biological effects of IGF-1 are mediated through binding to its high-affinity tyrosine kinase receptor (IGF1R), a transmembrane receptor belonging to the insulin receptor family.
Ángela García-Mato, Blanca Cervantes, Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, Isabel Varela-Nieto   +4 more
openaire   +4 more sources

Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]

, 2005
Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz, Mann, K., Ghosh, M., Machleidt, W., Machleidt, Werner, Siwanowicz, I., Ghosh, Madhumita, Holak, Tad A., Holak, T., Siwanowicz, Igor, Shanker, Sreejesh, Shanker, S.   +11 more
core   +1 more source

Insulin-like growth factor 1 and hair growth

Dermatology Online Journal, 1999
Insulin-like growth factor 1 (IGF-1) has been identified as an important growth factor in many biological systems.[1] It shares considerable structural homology with insulin and exerts insulin-like effects on food intake and glucose metabolism. Recently it has been suggested to play a role in regulating cellular proliferation and migration during the ...
Su, Hung-Yi, Hickford, Jonathan G H, Palmer, Barry R, Bickerstaffe, Roy   +3 more
openaire   +4 more sources

Heart Smart Insulin-Like Growth Factor 1 [PDF]

Hypertension, 2012
See related article, pp 680–693 The prevalence of obesity, metabolic syndrome, and type 2 diabetes mellitus, and the associated cardiac pathologies are rising to alarming levels. Conventional medical therapies for the prevention and treatment of cardiomyopathy are less effective in patients with these metabolic disorders, and this is attributed, at ...
Marsh, Susan A, Davidoff, Amy J
openaire   +3 more sources

IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

Frontiers in Endocrinology, 2018
Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
doaj   +1 more source

Effects of Insulin-Like Growth Factor (IGF-1) in Patients with Sensorineural Hearing Loss

, 2021
OBJECTIVES: (1) To test the effect of local administration of insulin-like growth factor-1 (IGF-1) in patients with sensorineural hearing loss (SNHL). (2) To test the effect of local administration of IGF-1 in patients with ototoxicity.
Varun Jitendra Dave, Kshitij Shah, Manish Prajapati, Joshi, Anagha, Shah, Kshitij, Renuka Bradoo, Dave, Varun Jitendra, Prajapati, Manish, Bradoo, Renuka, Anagha Joshi   +9 more
core   +1 more source

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection

Cell Death and Disease, 2022
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala, Kenneth Teel, Mohd A. Bhat, Albert Batushansky, Timothy M. Griffin, Lindsey Purcell, Raju V. S. Rajala   +6 more
doaj   +1 more source

Identification and characterization of insulin-like growth factor receptors on adult rat cardiac myocytes: linkage to inositol 1,4,5-trisphosphate formation. [PDF]

, 1992
Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of
Berg, Ingeborg, Guse, Andreas H., Kessler, Ulrike, Funk, Barbara, Gercken, Günther, A. H. Guse, Kiess, Wieland   +6 more
core   +2 more sources

Insulin-Like Growth Factor 1 in Patients with Hypoglycaemia [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1990
Plasma insulin-like growth factor 1 (IGF-1) concentrations were measured in a group of patients with hypoglycaemia due to endogenous hyperinsulinism, and compared with those in a group of patients matched for age and sex with hypoglycaemia and appropriately suppressed insulin levels. Insulin-like growth factor I concentrations were significantly higher
M, Labib, D, Teale, V, Marks
openaire   +2 more sources