Results 21 to 30 of about 622,044 (300)

Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength [PDF]

, 2020
Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves' ophthalmopathy. Other physiological roles of natural IGF1R-aAb are not known. We hypothesized that IGF1R-aAb may be related to muscle development.
Becker, Niels-Peter, Keller, Theresa, Kühnen, Peter, Minich, Waldemar B., Schomburg, Lutz, Schwiebert, Christian, Welsink, Tim, Wiegand, Susanna   +7 more
core   +1 more source

Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]

, 2011
Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Börzsönyi, Balázs, Csanád, Mónika, Demendi, Csaba, Joó József, Gábor, Nagy, Zsolt, Pajor, Attila, Rigó, János, Tóth, Katalin   +7 more
core   +2 more sources

Insulin-like growth factor 1 and hair growth

Dermatology Online Journal, 1999
Insulin-like growth factor 1 (IGF-1) has been identified as an important growth factor in many biological systems.[1] It shares considerable structural homology with insulin and exerts insulin-like effects on food intake and glucose metabolism. Recently it has been suggested to play a role in regulating cellular proliferation and migration during the ...
Su, Hung-Yi, Hickford, Jonathan G H, Palmer, Barry R, Bickerstaffe, Roy   +3 more
openaire   +4 more sources

IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?

Frontiers in Endocrinology, 2018
Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local tissues, most IGF molecules are bound by one of the members of the IGF ...
John B. Allard, Cunming Duan
doaj   +1 more source

Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection

Cell Death and Disease, 2022
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and ...
Ammaji Rajala, Kenneth Teel, Mohd A. Bhat, Albert Batushansky, Timothy M. Griffin, Lindsey Purcell, Raju V. S. Rajala   +6 more
doaj   +1 more source

Biomarkers of systemic inflammation and growth in early infancy are associated with stunting in young Tanzanian children [PDF]

, 2018
Stunting can afflict up to one-third of children in resource-constrained countries. We hypothesized that low-grade systemic inflammation (defined as elevations in serum C-reactive protein or alpha-1-acid glycoprotein) in infancy suppresses the growth ...
Aboud, Said, Duggan, Christopher P., Fawzi, Wafaie W., Kisenge, Rodrick, Liu, Enju, Locks, Lindsey, Manji, Karim P., McDonald, Christine M., Sudfeld, Christopher, Syed, Sana   +9 more
core   +1 more source

Insulin-like Growth Factor 1 and Transforming Growth Factor-β Stimulate Cystine/Glutamate Exchange Activity in Dental Pulp Cells [PDF]

, 2011
Introduction The growth factors insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) are protective to dental pulp cells in culture against the toxicity of the composite materials Durafill VS and Flow Line (Henry Schein Inc, New ...
Alyssa Furey, Asrari, Barthel, Bègue-Kirn, Cabrera, Camargo, Doug Lobner, Duailibi, D’Souza, Fogal, Franco, Furey, Goldberg, Gronthos, Hansen, Hu, Kalyva, Katherine Pauly, Kaur, Keelan, Kim, Kim, Kymberly Fritz, Lobner, Lovschall, Marcato, Nie, Onishi, Pacheco, Paranjpe, Piani, Piattelli, Ricketts, Rutherford, Stanley, Stockton, Tziafas, Tziafas, Ward, Wood   +39 more
core   +2 more sources

Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress [PDF]

, 2014
Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms.
Page, Melissa M., Robb, Ellen L., Selman, Colin, Sinclair, Amy, Stuart, Jeffrey A., Withers, Dominic J.   +5 more
core   +1 more source

Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin. [PDF]

, 2019
IntroductionDysferlin loss-of-function mutations cause muscular dystrophy, accompanied by impaired membrane repair and muscle weakness. Growth promoting strategies including insulin-like growth factor 1 (IGF-1) could provide benefit but may cause ...
Barton, Elisabeth R, Brisson, Becky K, Hammers, David W, Liu, Min, Park, SooHyun, Pham, Jennifer, Smith, Lucas R, Sweeney, H Lee, Tian, Zuozhen, Vassilakos, Georgios   +9 more
core   +1 more source

Quantitative analysis of insulin-like growth factor 2 receptor and insulin-like growth factor binding proteins to identify control mechanisms for insulin-like growth factor 1 receptor phosphorylation [PDF]

, 2016
Experimental results for the determination of internalization rates for IGF1-IGF1R, IGF2-IGF1R, IGF2-IGF2R.
Dan Tian, Isaiah Mitchell, Pamela K. Kreeger   +2 more
core   +5 more sources