Results 31 to 40 of about 34,929,961 (249)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A Unique Case of IGF-2 Induced Hypoglycemia Associated with Hepatocellular Carcinoma

Case Reports in Endocrinology, 2019
Tumor-induced hypoglycemia (TIH) associated with hepatocellular carcinoma (HCC) results from tumor production of insulin-like growth factor 2 (IGF-2), resulting in recurrent hypoglycemia. Serum levels of insulin-like growth factor 1 (IGF-1), insulin-like
Prachi Rana, Brian Kim
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

About evaluation of nutritive state in premature infants

Детские инфекции (Москва), 2021
Insulin-like growth factor 1 (IGF-1) plays an important role in the energy balance of the newborn baby's body, is associated with protein stores, which allows us to consider its level as an indicator of nutritional status.Objective: to study the value of
K. V. Dashichev, N. V. Olendar, T. G. Pukhova, E. P. Sitnikova   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Insulin‐like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

EMBO Molecular Medicine, 2014
Insulin‐like growth factor 2 (IGF2) was recently found to play a critical role in memory consolidation in rats and mice, and hippocampal or systemic administration of recombinant IGF2 enhances memory.
Maria Pascual‐Lucas, Silvia Viana da Silva, Marianna Di Scala, Carolina Garcia‐Barroso, Gloria González‐Aseguinolaza, Christophe Mulle, Cristina M Alberini, Mar Cuadrado‐Tejedor, Ana Garcia‐Osta   +8 more
doaj   +1 more source

Overexpression of IGF2 and IGF2 receptor in malignant solitary fibrous tumor with hypoglycemia: a case report

Surgical Case Reports, 2018
Background Solitary fibrous tumor (SFT) is a prototypical mesenchymal neoplasm that induces non-islet cell tumor hypoglycemia (NICTH) due to overproduction of insulin-like growth factor 2 (IGF2). We here report the case of a malignant SFT associated with
Yusuke Arakawa, Hidenori Miyake, Hidehisa Horiguchi, Taku Inokuchi, Naoki Hino, Takashi Ogasawara, Takeshi Kuroda, Shinichi Yamasaki   +7 more
doaj   +1 more source

Glucokinase links Kruppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease [PDF]

, 2011
The polymorphism, KLF6-IVS1-27A, in the Krüppel-like factor 6 (KLF6) transcription factor gene enhances its splicing into antagonistic isoforms and is associated with delayed histological progression of nonalcoholic fatty liver disease (NAFLD).
Gastaldelli, Amalia, Lee, Y., Isabel Fiel, Elisabetta Bugianesi, Miele, L., Lee, U., Bugianesi, E., Emma Buzzigoli, Andrea Mari, Pascoe, L., Mark Walker, Christopher P. Day, Burt, Alastair D., Walker, M., Bechmann, L., Hui, Kei Y, Fiel, I., Buzzigoli, E., Bechmann, Lars P., Miele, Luca, Fiel, Isabel., Luca Miele, Mari, Andrea, Patman, G., Ursula Muñoz, Day, Christopher P., Vetter, Diana., Burt, A., Lee, Young-Min., Munoz, Ursula., Hannivoort, Rebekka A., Alastair D. Burt, Amalia Gastaldelli, Walker, Mark., Agius, Loranne, Mari, A., Agius, Loranne., et al., Buzzigoli, Emma, Walker, Mark, Loranne Agius, Scott L. Friedman, Lee, Young-Min, Pascoe, Laura., Miele, Luca., Munoz, Ursula, Hui, K., Day, C., Laura Pascoe, Pascoe, Laura, Gastaldelli, Amalia., Fiel, Isabel, Ursula E. Lee, Gillian L. Patman, Munoz, U., Kei Y. Hui, Agius, L., Mari, Andrea., Vetter, D., Demetrio Ciociaro, Ciociaro, D., Buzzigoli, Emma., Lars P. Bechmann, Helen L. Reeves, Patman, Gillian L., Hannivoort, Rebekka A ., Ciociaro, Demetrio, Ciociaro, Demetrio., Mu?oz, Ursula, Bugianesi, Elisabetta, Diana Vetter, Reeves, Helen L., Hannivoort, R., Lee, Ursula E., Rebekka A. Hannivoort, Bugianesi, Elisabetta., Young-Min Lee, Vetter, Diana, Hui, Kei Y., Friedman, Scott L., Gastaldelli, A.   +80 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Intraoperative glycemic control using an artificial endocrine pancreas in a patient with a recurrent pleural solitary fibrous tumor producing insulin-like growth factor 2: a case report

JA Clinical Reports, 2019
Background Non-islet cell tumor producing insulin-like growth factor 2 involves hypoglycemia. During tumor resection, intense fluctuation of blood glucose level may occur. An artificial endocrine pancreas has been reported as beneficial for patients with
Kenzaburou Sugimoto, Rina Tokitou, Mamoru Kadosaki, Mamoru Takeuchi   +3 more
doaj   +1 more source