Results 11 to 20 of about 405,429 (298)

Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3 [PDF]

FEBS Letters, 2001
In the circulation, most of the insulin‐like growth factors (IGFs) are bound to a ternary 150 kDa complex with IGF‐binding protein (IGFBP)‐3 and the acid labile subunit. In the current study, we identify transferrin (Tf) by mass spectrometry, and immunoprecipitation as a component of a major IGF‐binding fraction separated from human plasma.
Storch, S., Kubler, B., Honing, S., Ackmann, M., Zapf, J., Blum, W., Braulke, Thomas   +6 more
openaire   +3 more sources

Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis [PDF]

, 2012
Extracellular matrix deposition and tissue scarring characterize the process of fibrosis. Transforming growth factor beta (TGFβ) and Insulin-like growth factor binding protein-3 (IGFBP-3) have been implicated in the pathogenesis of fibrosis in various ...
Adriana T. Larregina, Carol A. Feghali-Bostwick, Joseph M. Pilewski, Logan R. Mlakar, Sebastien Fuchs, Ximena D. Ruiz, Yukie Yamaguchi, Yunyun Su   +7 more
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Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-3 in Alzheimer's Disease [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2012
Few large studies have been conducted to assess the relationship between circulating IGF and late-life cognition.The aim of the study was to assess the relationship between IGF-I and IGF binding protein-3 (IGFBP-3) serum levels and cognitive impairment, including Alzheimer's disease (AD).In this multicentric cross-sectional study, 694 elderly subjects (
Duron, Emmanuelle, Funalot, Benoît, Brunel, Nadège, Coste, Joël, Quinquis, Laurent, Viollet, Cécile, Belmin, Joël, Jouanny, Pierre, Pasquier, Florence, Tréluyer, Jean-Marc, Epelbaum, Jacques, Le Bouc, Yves, Hanon, Olivier   +12 more
openaire   +3 more sources

The Aberrant Expression of MicroRNA-125a-5p/IGF2BP3 Axis in Advanced Gastric Cancer and Its Clinical Relevance

Technology in Cancer Research & Treatment, 2020
RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS, Fanghui Ding MD, Dan Jiao MS, Qiaozhi Li MS, Hong Ma MS   +4 more
doaj   +1 more source

Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2015
Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response
Min Sun Kim, Dae-Yeol Lee
doaj   +1 more source

Insulin-like Growth Factor-binding Protein-3 Binds Fibrinogen and Fibrin [PDF]

Journal of Biological Chemistry, 1999
Following tissue injury, a fibrin network formed at the wound site serves as a scaffold supporting the early migration of stromal cells needed for wound healing. Growth factors such as insulin-like growth factor-I (IGF-I) concentrate in wounds to stimulate stromal cell function and proliferation.
P G, Campbell, S K, Durham, J D, Hayes, A, Suwanichkul, D R, Powell   +4 more
openaire   +2 more sources

Cardiovascular disease risk markers in children under 10 years of age and their relationship with serum concentrations of IGF-1, IGFBP-1, IGFBP-2 and IGFBP-3

Revista de la Facultad de Medicina, 2020
Introduction: Any type of nutritional imbalance experienced during childhood will affect the health of an individual, both in their childhood and their adulthood.
Sorany Vera, Tatiana Figueroa, Luz Helena Aranzalez, Ismena Mockus   +3 more
doaj   +1 more source

Kinetics of urinary cell cycle arrest markers for acute kidney injury following exposure to potential renal insults [PDF]

, 2018
Objectives: Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 predict the development of acute kidney injury following renal insults of varied aetiology.
Aliaga, Bellomo, Bihorac, Bonventre, Charlton, Emlet, Goldstein, Gunnerson, Honore, Hoste, Hoste, Jia, Joannidis, Kane-Gill, Kashani, Kaufman, Kerr, Lewington, McDonald, Meersch, Mehta, Mehta, Murrary, Peng, Perazella, Uchino, Waring, Wu   +27 more
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Factors regulating insulin-like growth factor-binding protein-3 binding, processing, and potentiation of insulin-like growth factor action [PDF]

Endocrinology, 1996
In this study, we investigated the effects of various biochemical and pharmacological agents on insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) cell binding and action in cultured bovine fibroblasts. When cells were preincubated for 48 h with 50 nM recombinant human (rh) IGFBP-3, IGF-I-stimulated [3H]aminoisobutyric acid ([125H]AIB) uptake
C A, Conover, J T, Clarkson, L K, Bale
openaire   +4 more sources

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits [PDF]

, 2016
The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including ...
Aschard, H. (Hugues), Bandinelli, S. (Stefania), Beekman, M. (Marian), Berndt, S.I. (Sonja), Bidlingmaier, M. (Martin), Broer, L. (Linda), Cappola, A.R. (Anne), Ceda, G.P. (Gian Paolo), Chanock, S.J. (Stephen), Chen, M.-H. (Ming-Huei), Chen, T.C. (Tai C.), Chen, Y.D. (Y.), Chung, J. (Jonathan), Del Greco Miglianico, F. (Fabiola), Duijn, C.M. (Cornelia) van, Eriksson, J. (Joel), Ferrucci, L. (Luigi), Friedrich, N. (Nele), Gnewuch, C. (Carsten), Goodarzi, M. (Mark), Grarup, N. (Niels), Guo, T. (Tingwei), Hammer, E. (Elke), Hayes, R.B. (Richard), Heemst, D. (Diana) van, Hicks, A.A. (Andrew), Hofman, A. (Albert), Houwing-Duistermaat, J.J. (Jeanine), Hu, F. (Frank), Hunter, D. (David), Husemoen, L.L.N. (Lise Lotte), Isaacs, A.J. (Aaron), Jacobs, K.B. (Kevin), Janssen, J.A.M.J.L. (Joop), Jansson, J.-O. (John-Olov), Jehmlich, N. (Nico), Johnson, S. (Simon), Juul, A. (Anders), Kaplan, R.C. (Robert), Karlsson, M. (Magnus), Kilpeläinen, T.O. (Tuomas), Kovacs, P. (Peter), Kraft, P. (Peter), Li, C. (Chao), Linneberg, A. (Allan), Liu, Y. (YongMei), Loos, R.J.F. (Ruth), Lorentzon, M. (Mattias), Lu, Y. (Yingchang), Maggio, M. (Marcello), Meigs, J.B. (James), Mellström, D. (Dan), Mägi, R. (Reedik), Nauck, M. (Matthias), Nethander, M. (Maria), Newman, A.B. (Anne B.), Ohlsson, C. (Claes), Pollak, M.N. (Michael), Pramstaller, P.P. (Peter Paul), Prokopenko, I. (Inga), Psaty, B.M. (Bruce), Qi, Q., Reincke, M. (Martin), Rimm, E.B. (Eric B.), Rotter, J.I. (Jerome I.), Saint Pierre, A. (Aude), Schurmann, C. (Claudia), Seshadri, S. (Sudha), Sjögren, K. (Klara), Slagboom, P.E. (Eline), Strickler, H.D. (Howard D.), Stumvoll, M. (Michael), Suh, Y. (Yousin), Sun, Q. (Qi), Svensson, J. (Johan), Tanaka, T. (Toshiko), Tare, A. (Archana), Teumer, A. (Alexander), Tönjes, A. (Anke), Uh, H.-W. (Hae-Won), Vandenput, L. (Liesbeth), Vasan, R.S. (Ramachandran Srini), Völker, U. (Uwe), Wallaschofski, H. (Henri), Willems, S.M. (Sara), Zhang, C. (Cuilin)   +85 more
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