Results 11 to 20 of about 206,404 (257)
Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function [PDF]
Breast Cancer Research, 2002 Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of ...
Marshman, Emma, Streuli, Charles H.
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The Role of Insulin-Like Growth Factor Binding Proteins
Neuroendocrinology, 2006 Insulin-like growth factors (IGFs) are fundamental cell regulators with an evolutionary conserved role synchronising tissue growth, development and function according to metabolic conditions. Although structurally very similar to insulin, the IGFs act in a very different way as cell regulators. Whereas insulin is stored in a specific gland and released
Perks, Claire, Holly, Jeffrey M P
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The Role of Insulin-Like Growth Factors and Insulin-Like Growth Factor-Binding Proteins in the Nervous System. [PDF]
Biochem Insights, 2019 The insulin-like growth factors (IGF-I and IGF-II) and their receptors are widely expressed in nervous tissue from early embryonic life. They also cross the blood brain barriers by active transport, and their regulation as endocrine factors therefore differs from other tissues.
Lewitt MS, Boyd GW.
europepmc +4 more sources
Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases. [PDF]
Front Endocrinol (Lausanne), 2018 Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6.
Ding H, Wu T.
europepmc +2 more sources
Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes. [PDF]
Front Endocrinol (Lausanne), 2018 The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation-with six core Igfbps expanded into a family
Garcia de la Serrana D, Macqueen DJ.
europepmc +8 more sources
Transferrin binds insulin‐like growth factors and affects binding properties of insulin‐like growth factor binding protein‐3 [PDF]
FEBS Letters, 2001 In the circulation, most of the insulin‐like growth factors (IGFs) are bound to a ternary 150 kDa complex with IGF‐binding protein (IGFBP)‐3 and the acid labile subunit. In the current study, we identify transferrin (Tf) by mass spectrometry, and immunoprecipitation as a component of a major IGF‐binding fraction separated from human plasma.
Storch, S. +6 more
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Insulin-like growth factor binding proteins: a structural perspective. [PDF]
Front Endocrinol (Lausanne), 2012 Insulin-like growth factor binding proteins (IGFBP-1 to -6) bind insulin-like growth factors-I and -II (IGF-I and IGF-II) with high affinity. These binding proteins maintain IGFs in the circulation and direct them to target tissues, where they promote cell growth, proliferation, differentiation, and survival via the type 1 IGF receptor.
Forbes BE, McCarthy P, Norton RS.
europepmc +6 more sources
Indian J Med Paediatr Oncol, 2017 Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally, insulin is associated with metabolism, whereas Insulin like growth factors (IGFs) are involved in ...
Amutha P, Rajkumar T.
europepmc +4 more sources
Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]
, 2005 Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz +12 more
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Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]
, 2011 Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Tóth, Katalin +23 more
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