Animals, 2022 The relevance of the insulin-like growth factor-1 (IGF-1) system in several physiological processes is well-known in vertebrates, although little information about their temporal organization is available.
Aitana Alonso-Gómez +4 more
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Proteolysis of insulin-like growth factor binding proteins (IGFBPs) by calpain [PDF]
, 2005 Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are ubiquitously distributed across cell types and vertebrate species. The rules that govern calpain specificity have not yet been determined.
Mann, Karlheinz +12 more
core +1 more source
Gene expression patterns of insulin-like growth factor 1, insulin-like growth factor 2 and insulin-like growth factor binding protein 3 in human placenta from pregnancies with intrauterine growth restriction [PDF]
, 2011 Introduction: In this study, we compared insulin-like growth factor (IGF)-gene expression patterns and characteristics of glucose and insulin metabolism in human placenta from pregnancies with or without intrauterine growth restriction (IUGR).
Tóth, Katalin +23 more
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Insulin-like growth factor binding proteins initiate cell death and extracellular matrix remodeling in the mammary gland [PDF]
, 2005 We have demonstrated that insulin-like growth factor binding protein-5 (IGFBP-5) production by mammary epithelial cells increases dramatically during forced involution of the mammary gland in rats, mice and pigs.
Beattie, J +19 more
core +1 more source
Technology in Cancer Research & Treatment, 2020 RNA-binding proteins have been associated with cancer development. The overexpression of a well-known RNA-binding protein, insulin-like growth factor 2 messenger RNA–binding protein 3, has been identified as an indicator of poor prognosis in patients ...
Jing Zhang MS +4 more
doaj +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo. [PDF]
FEBS Open BioTo test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Yao S, Archetti M.
europepmc +2 more sources
Animal insulin-like growth factor binding proteins and their biological functions
Veterinární Medicína, 2002 Insulin-like growth factor (IGF-I, IGF-II) action is influenced by until today known eight forms of insulin-like growth factor binding proteins (IGFBPs).
Z. Kostecká, J. Blahovec
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Insulin-like growth factor (IGF)-I and IGF binding proteins axis in diabetes mellitus [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2015 Increasing evidence suggests an important role of the insulin-like growth factor (IGF)-IGF binding protein (IGFBP) axis in the maintenance of normal glucose and lipid metabolism. Significant changes occur in the local IGF-I-IGFBPs environment in response
Min Sun Kim, Dae-Yeol Lee
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Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins [PDF]
Proceedings of the National Academy of Sciences, 2006 Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. IGF-binding sites are found on N- and C-terminal fragments of IGFBPs, the two conserved domains of IGFBPs.
Sitar, T. +4 more
openaire +3 more sources
Advanced Biomedical Research, 2015 Background: The effect of the growth hormone on target cells is mediated by the insulin-like growth factor 1 (IGF-1). IGF-1 binds to the insulin-like growth factor binding proteins (IGFBPs) in blood and biological fluids.
Emad Khodadadi +4 more
doaj +1 more source