Insulin-Like Growth Factor Binding Proteins in Kidney Disease [PDF]
Frontiers in Pharmacology, 2021 The seven members of the insulin-like growth factor (IGF) binding protein family (IGFBPs) were initially considered to be the regulatory proteins of IGFs in the blood circulation, mainly as the subsequent reserve for bidirectional regulation of IGF ...
Shuqiang Wang +4 more
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Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes [PDF]
Frontiers in Endocrinology, 2018 The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified
Daniel Garcia de la Serrana +1 more
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Insulin-like growth factor binding proteins: a structural perspective [PDF]
Frontiers in Endocrinology, 2012 Insulin-like growth factor binding proteins (IGFBP-1 to -6) bind insulin-like growth factors-I and -II (IGF-I and IGF-II) with high affinity. These binding proteins maintain IGFs in the circulation and direct them to target tissues, where they promote ...
Briony eForbes +2 more
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Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases [PDF]
Frontiers in Endocrinology, 2018 Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6.
Huihua Ding, Tianfu Wu
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Insulin-like growth factors: Ligands, binding proteins, and receptors
Molecular Metabolism, 2021 Background: The insulin-like growth factor family of ligands (IGF-I, IGF-II, and insulin), receptors (IGF-IR, M6P/IGF-IIR, and insulin receptor [IR]), and IGF-binding proteins (IGFBP-1-6) play critical roles in normal human physiology and disease states.
Derek LeRoith +2 more
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Insulin-like growth factor binding proteins in metabolic dysfunction-associated steatotic liver disease [PDF]
Frontiers in EndocrinologyMetabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent condition that progresses from hepatic steatosis to steatohepatitis, fibrosis, and cirrhosis.
Kuo Fang +4 more
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Proteomics discovery of pulmonary hypertension biomarkers: Insulin‐like growth factor binding proteins are associated with disease severity [PDF]
Pulmonary Circulation, 2022 Pulmonary arterial hypertension (PAH) is a progressive disease characterized by sustained elevations of pulmonary artery pressure. To date, we lack circulating, diagnostic, and prognostic markers that correlate to clinical and functional parameters.
Melanie K. Nies +12 more
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Investigation of insulin-like growth factors/insulin-like growth factor binding proteins regulation in metabolic syndrome patients [PDF]
BMC Research Notes, 2019 Objective The insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are thought to play a significant role in metabolic pathways and glucose metabolism.
Somayeh Pouriamehr +4 more
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Indian Journal of Medical and Paediatric Oncology, 2017 Insulin and IGFs play an important role in cancer initiation and progression, including ovarian cancer (OC). Epithelial ovarian cancer (EOC) is the most frequent type of OC in women and it is the most lethal gynecological malignancy worldwide. Generally,
Periyasamy Amutha, Thangarajan Rajkumar
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Pan‐cancer analysis of oncogenic role of insulin‐like growth factor‐binding proteins and validation in ovarian cancer [PDF]
Cancer Medicine, 2023 Background Numerous studies have shown that the insulin‐like growth factor (IGF) pathway is highly associated with tumor initial and progression in several tumors.
Wei Tan +6 more
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