Evolution of ancient functions in the vertebrate insulin-like growth factor system uncovered by study of duplicated salmonid fish genomes [PDF]
, 2013 This work was supported by the Marine Alliance for Science and Technology for Scotland pooling initiative, funded by the Scottish Funding Council (grant number HR09011) and contributing institutions.Whole genome duplication (WGD) was experienced twice by
Macqueen, Daniel J +6 more
core +1 more source
Cellular Actions of Insulin-Like Growth Factor Binding Proteins [PDF]
Hormone and Metabolic Research, 1999 The insulin-like growth factors (IGFs), insulin-like growth factor binding proteins (IGFBPs), and the IGFBP proteases are involved in the regulation of somatic growth and cellular proliferation both in vivo and in vitro. IGFs are potent mitogenic agents whose actions are determined by the availability of free IGFs to interact with the IGF receptors ...
R J, Ferry +4 more
openaire +2 more sources
Insulin-Like Growth Factor (IGF)-I and -11 and IGFBinding Proteins-l, -2, and -3 in Children and Adolescents with Diabetes Mellitus: Correlation with Metabolic Control and Height Attainment. [PDF]
, 1995 The putative effects of diabetes and metabolic control on circulating levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) remain controversial.
Past, Roswitha +6 more
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IGFBP-1 marker of cervical ripening and predictor of preterm birth [PDF]
Medicinski Glasnik, 2016 Aim To establish a correlation between positive values of IGFBP-1 (>10 mg/L, Actim Partus Test, APT) and premature cervical ripening in imminent preterm labor. Methods A prospective study was conducted in primary health care centers in Tuzla, Gynecology
Larisa Mešić Ðogić +4 more
doaj +1 more source
Consequences of Postnatally Elevated Insulin-Like Growth Factor-II in Transgenic Mice: Endocrine Changes and Effects on Body and Organ Growth. [PDF]
, 1994 Insulin-like growth factor-II (IGF-II) is an important regulator of embryonic growth and differentiation, but its function in postnatal life is unclear. To address this point, we generated transgenic mice harboring fusion genes in which a human IGF-II
E. Wolf +10 more
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Przegląd Dermatologiczny, 2020 Insulin-like growth factor 1 belongs to the group of polypeptide growth factors. It plays a special role in the regulation of pre- and postnatal growth of the organism, and also has a hypoglycaemic, neuro-, and osteo- and chondroprotective effect ...
Magda Marek-Safiejko +3 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2022 Insulin-like growth factor 2 (IGF2) mRNA binding proteins (IMPs) family belongs to a highly conserved family of RNA-binding proteins (RBPs) and is responsible for regulating RNA processing including localization, translation and stability. Mammalian IMPs
Xiao Xu +3 more
doaj +1 more source
Comparative endocrinology of the insulin-like growth factor-binding protein [PDF]
Journal of Endocrinology, 2002 Abstract Emerging early in chordate evolution, the IGF-regulatory axis diverged from an insulin-like predecessor into a vertebrate regulatory system specializing in cell growth activation and allied anabolic functions. Essential to the divergence of the IGF and insulin systems was an early presence of soluble IGF-binding proteins ...
K M, Kelley +9 more
openaire +2 more sources
Insulin-Like Growth Factor II (IGF-II) Is More Potent Than IGF-I in Stimulating Cortisol Secretion from Cultured Bovine Adrenocortical Cells: Interaction with the IGF-I Receptor and IGF-Binding Proteins [PDF]
, 1995 Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown.
Weber, Matthias M. +4 more
core +2 more sources
Insulin-like growth factor-I and its binding proteins in healthy mothers and their newborns [PDF]
Einstein (São Paulo), 2004 Objective: To determine serum levels of insulin-like growth factor-I, free insulin-like growth factor-I and its binding proteins in maternalserum and in cord blood of two groups of newborns with differentbirth weights.
Rosanna Velleca Lima +3 more
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