Results 191 to 200 of about 361,919 (237)

Insulin‐like growth factor‐binding protein 1 and insulin‐like growth factor‐binding protein 3 in pre‐eclampsia

BJOG: An International Journal of Obstetrics & Gynaecology, 1996
Objective To investigate circulating levels of insulin‐like growth factor‐binding protein 1 (IGFBP‐1) and IGFBP‐3 in the mother and the fetus in pregnancies complicated by pre‐eclampsia, and the relationship between serum levels of IGFBPs and fetal birthweight.Design A prospective study over an 18 month period.Setting A tertiary care ...
H S, Wang, J D, Lee, B J, Cheng, Y K, Soong   +3 more
openaire   +2 more sources

Insulin-like growth factors, insulin-like growth factor-binding proteins, insulin-like growth factor-binding protein-3 protease, and growth hormone-binding protein in lipodystrophic Human Immunodeficiency Virus-infected patients

Metabolism, 2004
Human immunodeficiency virus (HIV)-lipodystrophy is associated with impaired growth hormone (GH) secretion. It remains to be elucidated whether insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), IGFBP-3 protease, and GH-binding protein (GHBP) are abnormal in HIV-lipodystrophy.
Steen B, Haugaard, Ove, Andersen, Birgitte R, Hansen, Hans, Orskov, Ulrik B, Andersen, Sten, Madsbad, Johan, Iversen, Allan, Flyvbjerg   +7 more
openaire   +2 more sources

Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts

American Journal of Physiology-Endocrinology and Metabolism, 1998
Insulin-like growth factors (IGFs) I and II are considered to be autocrine regulators of bone cell function. Recently, we demonstrated that IGF-I induces IGF-binding protein-5 (IGFBP-5) expression in cultures of osteoblast-enriched cells from 22-day fetal rat calvariae (Ob cells).
B, Gabbitas, E, Canalis
openaire   +2 more sources

Insulin-like growth factor binding proteins

1997
The insulin-like growth factor binding proteins (IGFBPs) bind both IGF-I and IGF-II with high affinity. They control IGF half-lives, rates of efflux from the vascular space, distribution within extracellular fluids, and their equilibrium with cell surface receptors.
openaire   +1 more source

Insulin-like Growth Factor Binding Proteins

1993
Publisher Summary This chapter discusses the insulin-like growth factor (IGF) binding proteins—namely, IGF-I and IGF-II. The IGFs are purified from human plasma and cell culture medium by virtue of their ability to stimulate the growth of cartilage or cultured fibroblasts, or their insulin-like activity.
openaire   +2 more sources

Insulin-like growth factor receptors and binding proteins

Baillière's Clinical Endocrinology and Metabolism, 1996
The insulin-like growth factor receptors are integral membrane proteins and demonstrate separate, but important effects on the regulation of cellular processes. The IGF-I receptor signals multiple cascades via its inherent tyrosine kinase activity. The IGF-II/M-6-P receptor on the other hand is primarily involved in targeting of enzymes to various ...
openaire   +2 more sources

Insulin-Like Growth Factor-Binding Proteins and Ovarian Folliculogenesis

Hormone Research, 1996
In the ovary, insulin-like growth factors (IGFs) enhance both proliferation and differentiation of follicular cells by potentiating gonadotropin's actions. The biological effects of IGFs are strikingly modulated by IGF-binding proteins (IGFBPs), whose levels in follicular fluid dramatically change during folliculogenesis.
Monget, Philippe, Besnard, N., Huet, Camille, Pisselet, C., Monniaux, Danielle   +4 more
openaire   +3 more sources

Insulin-like growth factor binding proteins 4-6

Best Practice & Research Clinical Endocrinology & Metabolism, 2015
Insulin-like growth factor binding proteins (IGFBPs) 4-6 have important roles as modulators of IGF actions. IGFBP-4 and IGFBP-6 predominantly inhibit IGF actions, whereas IGFBP-5 may enhance these actions under some circumstances. IGFBP-6 is unique among the IGFBPs for its marked IGF-II binding preference.
openaire   +2 more sources

Insulin-like Growth Factor Binding Proteins in Development

2005
IGFBPs regulate growth and development by regulating IGF transport to tissues and IGF bioavailability to IGF receptors at cell membrane level. IGFBP excess leads predominantly to inhibition of IGF action and growth retardation with impaired organogenesis. Absence of human and also mouse ALS leads to decreased IGF-I levels in circulation and causes mild
Josef V, Silha, Liam J, Murphy
openaire   +2 more sources

Insulin-like growth factor binding protein (IGFBP) signalling

Growth Hormone & IGF Research, 2004
Insulin-like growth factor-I and -II (IGF-I and -II) are peptides that regulate cell metabolism, growth, differentiation and survival according to physiological requirements and the tissue type involved. They bind to two transmembrane receptors, the type I and type II IGF receptors (IGF-IR and IGF-IIR), although their cellular action is mediated via ...
openaire   +2 more sources