Results 191 to 200 of about 394,398 (350)

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

Journal of the National Cancer Institute, 2001
Yuhong Lu, X. Zi, Yunhua Zhao, D. Mascarenhas, M. Pollak   +4 more
semanticscholar   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Mediating effect of osteocalcin underlying the link between insulin-like growth factor-I and gestational diabetes mellitus. [PDF]

BMC Pregnancy Childbirth
Cui L, Gao Y, Sun R, Li Z, Zhang Z, Ji L, Wang Y, Ye H, Qin L.   +8 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Heritability and Correlation Estimates for Serum Insulin-like Growth Factor I Concentration, Weight, Weight Gain, and Height in Angus Beef Cattle in a Long-Term Divergent Selection Study for Serum Insulin-like Growth Factor I (1989 to 2017). [PDF]

Animals (Basel)
Davis ME, Simmen RCM.
europepmc   +1 more source

Rescue IVM of Denuded GV- and MI-Stage Oocytes of Premenopausal Rats with Oncostatin M, Insulin-like Growth Factor I, and Growth Hormone. [PDF]

Life (Basel), 2022
Akdemir Y, Donmez Cakil Y, Selam B, Sitar ME, Cincik M.   +4 more
europepmc   +1 more source

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells.

Cancer Research, 2005
R. Nahta, L. Yuan, Bing Zhang, R. Kobayashi, F. Esteva   +4 more
semanticscholar   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology. [PDF]

F1000Res, 2022
Zegarra-Valdivia J, Fernandez AM, Martinez-Rachadell L, Herrero-Labrador R, Fernandes J, Torres Aleman I.   +5 more
europepmc   +1 more source

Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function.

Proceedings of the National Academy of Sciences of the United States of America, 1998
E. Barton-Davis, D. Shoturma, A. Musarò, N. Rosenthal, And H Lee Sweeney   +4 more
semanticscholar   +1 more source