Results 211 to 220 of about 394,398 (350)

Hepatic Expression of Growth Hormone Receptor (<i>GHrec</i>) and Insulin-like Growth Factor-I (<i>IGF-I</i>) Genes and Cellular Location of <i>IGF-I</i> mRNA in Diploid and Triploid Atlantic Salmon (<i>Salmo salar</i>) Undergoing Parr-Smolt Transformation. [PDF]

Animals (Basel)
Bortoletti M, Fonsatti E, Maccatrozzo L, Peruzzi S, Jobling M, Vascellari M, Radaelli G, Bertotto D.   +7 more
europepmc   +1 more source

The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury. [PDF]

Int J Mol Sci, 2021
Munoz K, Wasnik S, Abdipour A, Bi H, Wilson SM, Tang X, Ghahramanpouri M, Baylink DJ.   +7 more
europepmc   +1 more source

The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila

, 2009
Insulin/IGF-like signalling (IIS) is an evolutionarily conserved pathway that has diverse functions in multi-cellular organisms. Mutations that reduce IIS can have pleiotropic effects on growth, development, metabolic homeostasis, fecundity, stress ...
Broughton, S., Ikeya, T., Partridge, L., Alic, N., Grandison, R.   +4 more
core  

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Associations between Bronchopulmonary Dysplasia, Insulin-like Growth Factor I and Nutrition. [PDF]

Nutrients
Yumani DFJ, Walschot FH, Lafeber HN, van Weissenbruch MM.   +3 more
europepmc   +1 more source

Functionally significant insulin-like growth factor I receptor mutations in centenarians

Proceedings of the National Academy of Sciences of the United States of America, 2008
Y. Suh, G. Atzmon, Miook Cho, David Hwang, Bingrong Liu, D. Leahy, N. Barzilai, P. Cohen   +7 more
semanticscholar   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Growth hormone/insulin-like growth factor I axis in health and disease states: an update on the role of intra-portal insulin. [PDF]

Front Endocrinol (Lausanne)
Yuen KCJ, Hjortebjerg R, Ganeshalingam AA, Clemmons DR, Frystyk J.   +4 more
europepmc   +1 more source

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse. [PDF]

Front Aging Neurosci, 2021
Zegarra-Valdivia JA, Chaves-Coira I, Fernandez de Sevilla ME, Martinez-Rachadell L, Esparza J, Torres-Aleman I, Nuñez A.   +6 more
europepmc   +1 more source

Developmentally Inspired Bioprinting of Nascent Multicellular Human Heart Tissue Through in Situ Differentiation and Morphogenesis of iPSCs

Advanced Science, EarlyView.
A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick, Juhi Chakraborty, Orlaith Kennedy, Hey Wei Wong, Sogol Kianersi, Daniel Kelly, Vasileios Sergis, Abhay Pandit, Andrew C. Daly   +8 more
wiley   +1 more source