Results 241 to 250 of about 31,941,529 (292)

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation

Advanced Science, EarlyView.
BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai, Xin Mei Zhang, Jing Cheng Zhang, Xu Ting Deng, Qiao Liu, Mustafa Hussein Ali, Fang Zhou Yin, Wu Yin   +7 more
wiley   +1 more source

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Insulin-like Growth Factor-I in Growth and Metabolism

Journal of Pediatric Endocrinology and Metabolism, 2010
Deficiency of insulin-like growth factor-I (IGF-I) results in growth failure. A variety of molecular defects have been found to underlie severe primary IGF-I deficiency (IGFD), in which serum IGF-I concentrations are substantially decreased and fail to respond to GH therapy.
Backeljauw, P, Bang, P, Dunger, D B, Juul, A, Le Bouc, Y, Rosenfeld, R   +5 more
openaire   +3 more sources

Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I

American Journal of Physiology-Renal Physiology, 1991
We report the localization of insulin-like growth factor I (IGF-I) and a 25-kDa form of insulin-like growth factor-binding protein (IGF-BP-1) in adult rat kidney. The antigens were localized using a rabbit anti-human IGF-I antibody, and a rabbit anti-human IGF-BP-1 antibody raised against human 25-kDa IGF-BP-1 purified from amniotic fluid ...
S, Kobayashi, D R, Clemmons, M A, Venkatachalam   +2 more
openaire   +2 more sources

Insulin-Like Growth Factor -I Deficiency

Hormone Research in Paediatrics, 2001
The insulin-like growth factor (IGF) system composed of two ligands, their receptors and regulatory proteins (acid-labile subunit and IGF-binding proteins) plays a central role in the regulation of growth and development in mammals. In addition to its key role in the stimulation of cellular proliferation and growth, IGF-I has important effects on ...
C, Camacho-Hübner, M, Savage
openaire   +2 more sources

Insulin-Like Growth Factor I

Drugs & Aging, 2000
According to the somatomedin model, growth hormone (GH)-dependent hepatic synthesis is responsible for maintaining circulating insulin-like growth factor (IGF)-I levels. On the other hand, the local autocrine/paracrine IGF-I expression in peripheral tissue is generally GH-independent and reflects the effects of various and tissue-specific trophic ...
ARVAT, Emanuela, BROGLIO, Fabio, GHIGO, Ezio   +2 more
openaire   +3 more sources

Insulin‐like growth factor I actions on steroidogenesis

Acta Paediatrica, 1994
The best evidence that insulin‐like growth factor I (IGF‐I) contributes to normal steroidogenesis comes from patients with growth hormone (GH) insensitivity syndrome due to deletion of the GH receptor gene. These patients have severe GH resistance and severe IGF‐I insufficiency, and present with markedly delayed puberty without gonadotrophin ...
Chatelain, P.G., Avallet, O., Nicolino, M., Lejeune, Hervé, Clark, A., Chuzel, F., Penhoat, Armelle, Saez, J.M.   +7 more
openaire   +3 more sources

Spatial and temporal expression of insulin-like growth factor-I, insulin-like growth factor-II and the insulin-like growth factor-I receptor in the sheep fetal mammary gland

Journal of Dairy Research, 1999
The mammary gland is an example of a tissue of epidermal origin that depends for the development of its characteristic morphology on underlying mesenchymal cells. The interaction between mesenchyme and epithelium appears to be mediated by polypetide growth factors.
Forsyth, Isabel A., Gabai, Gianfranco, Morgan, Geoff   +2 more
openaire   +4 more sources

Insulin-like growth factor-I and insulin-like growth factor-binding proteins in the nephrotic syndrome

Pediatric Nephrology, 1996
Similar to findings in the nephrotic syndrome in humans, rats with the doxorubicin-induced nephrotic syndrome (which resembles minimal change disease) have reduced serum levels of insulin-like growth factor-I (IGF-I). This is mainly caused by glomerular ultrafiltration of IGF-I-containing binding protein complexes, primarily of a molecular weight of ...
S M, Feld, R, Hirschberg
openaire   +2 more sources