Results 261 to 270 of about 31,941,529 (292)

Preparation of insulin-like growth factor I and photoaffinity labeling of insulin-like growth factor I receptor

Peptides, 1993
Recombinant human insulin-like growth factor I (hIGF-I) was reacted with azidobenzoyl hydroxysuccinimide to produce a mixture of photoactive hIGF-I derivatives. The mixture was purified by reversed-phase HPLC to yield three mono-substituted azidobenzoyl hIGF-Is.
Cecil C. Yip, Helga Hsu, Jerrold M. Olefsky, Lynn Seely   +3 more
openaire   +1 more source

Nutritional regulation of insulin-like growth factor-I

Metabolism, 1995
Several lines of evidence indicate that in the human, insulin-like growth factor-I (IGF-I) is nutritionally regulated. Both energy and protein availability are required for maintenance of IGF-I. Measurements of serum IGF-I constitute a sensitive means for monitoring the response of acutely ill patients to nutritional intervention.
J M, Ketelslegers, D, Maiter, M, Maes, L E, Underwood, J P, Thissen   +4 more
openaire   +2 more sources

Insulin-like growth factor-I and cancer risk

Growth Hormone & IGF Research, 2004
Growth factor pathways are fundamental in normal tissue regulation and development. In many tissues, factors that function in normal growth and development also have important regulatory roles in transformed malignant cells. The insulin-like growth factor (IGF) system is implicated in the regulation of the malignant phenotype by its effects on ...
Yasir H, Ibrahim, Douglas, Yee
openaire   +2 more sources

The insulin-like growth factor-I receptor as an oncogene

Archives of Physiology and Biochemistry, 2009
The insulin-like growth factor-I receptor (IGF-IR) mediates the biological actions of both IGF-I and IGF-II. The IGF-IR is expressed in most transformed cells, where it displays potent antiapoptotic, cell-survival, and transforming activities. IGF-IR expression is a fundamental prerequisite for the acquisition of a malignant phenotype, as suggested by ...
Haim, Werner, Ilan, Bruchim
openaire   +2 more sources

Defining Insulin-Like Growth Factor-I Deficiency

Hormone Research, 2006
• The GH-IGF system should be viewed like other endocrine systems, with a central, trophic hormone (GH) and a peripherally active hormone (IGF-I). • A decrease in IGF-I production, without a concomitant impairment in GH secretion, should be termed 'Primary IGF deficiency'.
openaire   +2 more sources

Insulin-like growth factor-I and diabetes. A review

Growth Hormone & IGF Research, 1998
Although diabetes is a heterogeneous condition, IGF-I has been shown to improve glycaemic control and reduce insulin requirements in both IDDM and NIDDM. In IDDM, the therapeutic rationale for IGF-I is as a replacement therapy "topping up" low circulating IGF-I levels.
Simpson, H L, Umpleby, A M, Russell-Jones, D L   +2 more
openaire   +3 more sources

Folding of Insulin-like Growth Factor I Is Thermodynamically Controlled by Insulin-like Growth Factor Binding Protein

Biochemistry, 1994
Insulin-like growth factor I (IGF-I) is thermodynamically unable to quantitatively form its native disulfides under reversible redox conditions in vitro [Hober et al. (1992) Biochemistry 31, 1749-1756]. These results prompted the question of how IGF-I may overcome this energetic problem in its folding in vivo.
S, Hober, A, Hansson, M, Uhlén, B, Nilsson   +3 more
openaire   +2 more sources

Acromegaly and Serum Insulin-Like Growth Factor I

Hormone Research in Paediatrics, 2004
Random levels of growth hormone (GH) are usually not helpful in diagnosing either GH deficiency or GH hypersecretion because GH is secreted in a pulsatile fashion. Insulin-like growth factor I (IGF-I), however, is a good indicator of GH secretion and action, particularly at the level of the liver.
openaire   +2 more sources

Localization of insulin-like growth factor binding protein-2 messenger RNA during postnatal brain development: Correlation with insulin-like growth factors I and II

Neuroscience, 1993
Carolyn A Bondy
exaly  

Binding and biological effects of insulin, insulin analogues and insulin-like growth factors in rat aortic smooth muscle cells. Comparison of maximal growth promoting activities

Diabetologia, 1991
Karin Bornfeldt, Hans Arnqvist, A Skottner   +2 more
exaly