Results 251 to 260 of about 31,941,529 (292)

Insulin-Like Growth Factor-I is Internalized after Binding to the Type I Insulin-Like Growth Factor Receptor

Hormone and Metabolic Research, 1989
Receptor-mediated endocytosis may represent an important mechanism whereby peptide hormones exert their biological effects. The ability of recombinant insulin-like growth factor (IGF)-I to be internalized by cultured cells was evaluated in BRL-3A2 cells, a rat liver-derived cell line which lacks insulin receptors.
E S, Geary, R G, Rosenfeld, A R, Hoffman
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Insulin‐like growth factor I in growing thoroughbreds

Journal of Animal Physiology and Animal Nutrition, 2007
SummaryThe objective of this longitudinal study was to characterize growth and plasma insulin‐like growth factor I (IGF‐I) concentrations in pasture‐raised thoroughbreds fed two sources of dietary energy. Mares and foals were randomly assigned to either a sugar and starch (SS) or fat and fibre (FF)‐rich feed, and plasma IGF‐I and growth were measured ...
W B, Staniar, D S, Kronfeld, R M, Akers, P A, Harris   +3 more
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Insulin-Like Growth Factor I: Pros and Cons of a Bioassay

Hormone Research in Paediatrics, 2011
Background: Insulin-like growth factor I (IGF-I) immunoassays are primarily used to estimate IGF-I status. Recently an IGF-I-specific kinase receptor activation assay (KIRA) was developed as an alternative method for measuring IGF-I bioactivity. When compared with IGF-I immunoassays, the IGF-I KIRA has the theoretical advantage of measuring the net ...
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Insulin-Like Growth Factor-I in Celiac Disease

Journal of Pediatric Gastroenterology and Nutrition, 1994
To contribute to the description of the physiopathological mechanisms of celiac disease, changes in insulin-like growth factor I (IGF-I) were followed-up in 21 children suspected of suffering from celiac disease. Thirteen children were suffering from celiac disease according to the original criteria of the European Society of Paediatric ...
B, Weile, P A, Krasilnikoff, A, Giwercman, N E, Skakkebaek   +3 more
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Effects of Insulin‐Like Growth Factor I in Man

Acta Paediatrica, 1990
ABSTRACT. A 6‐day period of subcutaneous infusion with recombinant human insulin‐like growth factor I in three healthy male volunteers resulted in an increase in the ratio of insulin to C‐peptide levels and significant decreases in triglyceride levels and the ratio of total to high density lipoprotein—cholesterol in serum.
Guler HP, Schmid C, Zapf J, Froesch ER
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Clinical Uses of Insulin-like Growth Factor I

Annals of Internal Medicine, 1994
Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions. The therapeutic potential of recombinant human IGF-I treatment is being investigated in various growth hormone-resistant and insulin-resistant disorders. Recent studies have shown that IGF-I may substitute for growth hormone in promoting linear
C A, Bondy, L E, Underwood, D R, Clemmons, H P, Guler, M A, Bach, M, Skarulis   +5 more
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Insulin-like growth factor-I: Clinical studies

Drugs of Today, 1998
Insulin-like growth factor-I (IGF-I) has endocrine, autocrine and paracrine properties. Receptors for IGF-I are present on virtually all cell types but are located mainly on cells of mesenchymal origin, such as fibroblasts, chondrocytes and osteoblasts. Growth hormone (GH)-dependent and GH-independent actions of IGF-I have been implicated in normal and
P E, Vos, H P, Koppeschaar, W R, de Vries, J H, Wokke   +3 more
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Growth hormone and insulin-like growth factor-I in odontogenesis

The International Journal of Developmental Biology, 1995
This review documents recent insights into the roles of growth hormone and insulin-like growth factor-I during tooth formation. Hereditarily growth hormone-deficient Lewis dwarf rats and hypophysectomized rats have been used to document the influence of growth hormone on growth of the rat incisor and molar teeth in vivo.
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Drug delivery of Insulin-like growth factor I

European Journal of Pharmaceutics and Biopharmaceutics, 2015
This review starts off outlining the control of Insulin-like growth factor I (IGF-I) kinetics in Nature and by virtue of a complex system of 6 binding proteins controlling half-life and tissue distribution of this strong anabolic peptide. In addition, alternative splicing is known to result in IGF-I variants with modulated properties in vivo and this ...
Isabel Schultz, Joel Wurzel, Lorenz Meinel   +2 more
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Exercise and Circulating Insulin-Like Growth Factor I

Hormone Research in Paediatrics, 2004
Determinations of serum concentrations of total insulin-like growth factor I (tIGF-I) are important in the diagnosis, monitoring of treatment and safety evaluation of patients with growth disorders and/or metabolic disease. It is well established that tIGF-I status varies over time.
Ulrika, Berg, Peter, Bang
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