Results 31 to 40 of about 530,055 (311)

Type I Insulin-like Growth Factor Receptor Induces Pulmonary Tumorigenesis

Neoplasia: An International Journal for Oncology Research, 2009
Despite the type I insulin-like growth factor receptor (IGF-IR) being highly expressed in more than 80% of human lung tumors, a transgenic model of IGF-IR overexpression in the lung has not been created.
Nicolle M. Linnerth, Megan D. Siwicky, Craig I. Campbell, Katrina L.M. Watson, James J. Petrik, Jeffrey A. Whitsett, Roger A. Moorehead   +6 more
doaj   +1 more source

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Insulin-like Growth Factor-I in Muscle Metabolism and Myotherapies

Neurobiology of Disease, 2001
The critical anabolic and trophic role of signaling by insulin-like growth factors (IGF) I and II via the type-I IGF receptor (IGF-IR) is reviewed throughout the life of skeletal myocytes.
J.Robinson Singleton, Eva L. Feldman
doaj   +1 more source

Cardiovascular Disease and Insulin-Like Growth Factor I [PDF]

Circulation, 2002
The research field of cardiovascular disease in regard to growth hormone (GH) and its mitogenic mediator insulin-like growth factor I (IGF-I) has a long and distinguished history and is still intensively studied. Medline searches reveal that more than 1000 articles have appeared, demonstrating the importance of IGF-I in development of (and for lesions ...
Frystyk, J., Ledet, T., Møller, N., Flyvbjerg, A., Ørskov, H.   +4 more
openaire   +2 more sources

The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells

Medicina, 2019
Background and objectives: Mounting evidence shows that curcumin, a bioactive substance originating from turmeric root, has anticancer properties. Additionally, curcumin prevents the migration and metastasis of tumor cells.
Seyed Ahmad Hosseini, Hamid Zand, Makan Cheraghpour   +2 more
doaj   +1 more source

Characteristics and treatment outcomes of micromegaly – acromegaly with apparently normal basal GH: A retrospective study and literature review

Endocrine Regulations, 2022
Objective. Micromegaly describes a subgroup of patients with clinically evident acromegaly and elevated insulin-like growth factor I (IGF-I) with apparently normal basal growth hormone (bGH) and often a glucose-suppressed growth hormone (GH) of
Inacio Isabel, Fonseca Liliana, Amado Ana, Benido Vania, Ribeiro Isabel, Dores Jorge, Amaral Claudia, Cardoso Maria Helena   +7 more
doaj   +1 more source

Plasma leptin and insulin-like growth factor I levels during acute exacerbations of chronic obstructive pulmonary disease [PDF]

, 2009
Background Recent studies have provided evidence for a link between leptin and tumor necrosis factor-alpha (TNF-α). Insulin-like growth factor I (IGF-I) mediates the metabolic effects of growth hormone (GH).
Prokopis Kythreotis, Ageliki Kokkini, Stavrina Avgeropoulou, Argyro Hadjioannou, Efgenia Anastasakou, Antonis Rasidakis, Petros Bakakos, AMWJ Schols, MAP Vermeeren, M Di Francia, I de Godoy, M Saetta, AMWJ Schols, EC Creutzberg, C Grunfeld, MS Zumbach, LS Matthews, S Scalvini, MA Spruit, T Crul, Y Iioka, L Burdet, GOLD, HC Lukaski, F Sakai, AM Schols, AGN Agusti, M Calikoglu, N Takabatake, S Papaspyrourao, S DagogoJack, AMWJ Schols, PA Tataranni, JH Pinkney, A Hjalmarsen, R Casaburi, CA Benbassat, CA Benbassat, I Vogiatzis   +38 more
core   +2 more sources

Glucose-dependent effect of insulin receptor isoforms on tamoxifen antitumor activity in estrogen receptor-positive breast cancer cells

Frontiers in Endocrinology, 2023
IntroductionBreast cancer is the most common malignancy in women, and it is linked to several risk factors including genetic alterations, obesity, estrogen signaling, insulin levels, and glucose metabolism deregulation.
Stefania Stella, Stefania Stella, Michele Massimino, Michele Massimino, Livia Manzella, Livia Manzella, Nunziatina Laura Parrinello, Silvia Rita Vitale, Silvia Rita Vitale, Federica Martorana, Federica Martorana, Paolo Vigneri, Paolo Vigneri, Paolo Vigneri   +13 more
doaj   +1 more source

Insulin-like growth factor I (IGF-I) and liver cirrhosis [PDF]

, 2007
Insulin-like growth factor I (IGF-I) is a polypeptide hormone secreted by multiple tissues in response to growth hormone (GH). It is partly responsible for GH activity, and also has glucose-lowering and anabolizing effects.
Conchillo, M. (M.), Prieto, J. (Jesús), Quiroga, J. (Jorge)   +2 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source