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Synthetic insulin-like growth factor II

Biochemical and Biophysical Research Communications, 1985
Human insulin-like growth factor II with 67 amino acid residues and three disulfide bridges has been synthesized by the solid-phase method. Homogeneity of the synthetic product is ascertained by chromatofocusing, high performance liquid chromatography and amino acid analysis.
C H, Li   +3 more
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Insulin‐Like Growth Factor II Effects Mediated through Insulin‐Like Growth Factor II Receptors

Acta Paediatrica, 1990
ABSTRACT. Insulin‐like growth factor II (IGF‐II) resembles the homologous peptide insulin‐like growth factor I (IGF‐I) in that it stimulates cellular growth in vitro. This effect is generally believed to be mediated through IGF type 1 receptors; the role of the IGF type 2 receptor remains, as yet, unknown.
M, Tally, K, Hall
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Immunoreactive insulin-like growth factor II in urine

Acta Endocrinologica, 1990
Abstract. Insulin-like growth factor II and insulin-like growth factor binding protein-1 were identified and quantified in the urine of 23 healthy subjects between 17 and 76 years of age. IGF-II was measured after separation by gel chromatography at low pH and compared with IGF-I levels in the same samples, whereas IGF binding protein-1 was measured in
W, Zumkeller, K, Hall
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Secretion of insulin-like growth factor II into milk

Biochemical and Biophysical Research Communications, 1992
125I-labeled insulin-like growth factor II (IGF-II) was infused directly into the pudic artery supplying one gland of lactating goats (n = 4). Maximum specific activity for [125I]IGF-II transferred into milk from the infused gland was reached 60 min after that in plasma and was 2.5 fold greater than in milk from the non-infused gland.
C G, Prosser, I R, Fleet
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Chemical synthesis of insulin‐like growth factor II

International Journal of Peptide and Protein Research, 1985
Human insulin‐like growth factor II (IGF‐II) with 67 amino acids and three disulfide bridges has been synthesized by the solid‐phase method. The synthetic hormone is shown to be homogeneous in high performance liquid chromatography (HPLC), high performance partition chromatography (HPPC), and chromatofocusing.
D, Yamashiro, C H, Li
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Insulin-Like Growth Factor II in Hepatocellular Carcinoma

Biomarkers in Medicine, 2007
Hepatocellular carcinoma is one of the most common malignant human tumors. Hepatocarcinogenesis is a multistep process with a multifactorial etiology. Chronic hepatitis B and hepatitis C virus infection, alcohol drinking and cirrhosis of any etiology are the major risk factors for hepatocellular carcinoma.
Jeng-Eing, Jeng   +4 more
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Identification of receptors for insulin-like growth factor II in two insulin-like growth factor II producing cell lines

Biochemical and Biophysical Research Communications, 1986
Specific high affinity membrane receptor(s) for insulin-like growth factor II have been characterized in two cell lines which produce this hormone and have the ability to proliferate in serum-free media. These receptor(s) have no affinity for either insulin or biosynthetic insulin-like growth factor I.
P D, Lee   +4 more
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Variable accumulation of insulin-like growth factor II in mouse tissues deficient in insulin-like growth factor II receptor

The International Journal of Biochemistry & Cell Biology, 1999
The insulin-like growth factor II receptor mediates endocytosis of insulin-like growth factor II, resulting in growth factor degradation in lysosomes. This degradation is an important regulator of growth factor activity in vivo, as shown by the phenotype of receptor deficient mice.
C M, Nolan, M A, Lawlor
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