Results 81 to 90 of about 22,902,059 (175)
The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila [PDF]
, 2009 Insulin/IGF-like signalling (IIS) is an evolutionarily conserved pathway that has diverse functions in multi-cellular organisms. Mutations that reduce IIS can have pleiotropic effects on growth, development, metabolic homeostasis, fecundity, stress ...
Broughton, S. +4 more
core
Progress of Research on Mechanism of Acupuncture for Diabetes Mellitus
针刺研究, 2018 Acupuncture has been used to treat diabetes mellitus(DM)for more than one thousand years.In the present paper,we review new progress of researches on the underlying mechanism of acupuncture intervention for DM.Results showed that acupuncture intervention
CHEN Chao +5 more
doaj +2 more sources
Study of the insulin-like peptide 3 in human platelets
, 2009 The insulin-like 3 peptide is autocrine/paracrine insulin-related hormone with a size of approximately 6kDa [1]. It mediates through a leucine richG-coupled receptor named LGR8. INSL3 is mainly expressed in human Leydig cells and is directly responsible for migration of the testis during the pre-natal period in maledevelopment.
openaire +1 more source
Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives
Acta Pharmaceutica Sinica BDiabetes, characterized by hyperglycemia, is a major cause of death and disability worldwide. Peptides, such as insulin and glucagon-like peptide-1 (GLP-1) analogs, have shown promise as treatments for diabetes due to their ability to mimic or enhance ...
Bingwen Ding +5 more
doaj +1 more source
The C. elegans insulin-like peptides (ILPs) [PDF]
Insulin and insulin-like peptides (ILPs) are conserved in living organisms to modulate homeostasis by functioning as ligands. For understanding of molecular mechanisms regulated by the ligands, the nematode Caenorhabditis elegans is a good model since: 1)
Kawano, Tsuyoshi +10 more
core +1 more source
Journal of DiabetologyBackground: Continuous subcutaneous insulin infusion (CSII) pump has shown good outcomes in patients with both type 1 and type 2 diabetes mellitus. Here, we present an individual with type 2 diabetes and obesity who was on a high dosage of insulin and ...
Brijendra Kumar Srivastava +5 more
doaj +1 more source
Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]
, 2013 Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Parthsarathy, Vadivel +1 more
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Glucagon-like peptide 1 is a hormone involved in the regulation of glucose. Glucose-dependent activation of brain GLP-1R stimulates GLP-1 secretion from the L-cells of the intestine in response to ingested nutrients and it enters the blood stream to ...
Robinson, Louise E.
core
The modification of insulin to enhance oral delivery systems [PDF]
, 2009 textWhile a number of PEGylated proteins have been studied for injectable applications and reviewers have used this data to speculate possible oral delivery improvements, a detailed investigation of PEGylated insulin for oral delivery and the development
Kanzelberger, Melissa Ann
core
Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance
Nature CommunicationsOrchestrated hormonal interactions in response to feeding and fasting play a pivotal role in regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin-like 3 (FSTL3), an endogenous inhibitor of Activin B, in adipose ...
Naoki Kobayashi +17 more
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