Results 211 to 220 of about 2,026,798 (359)

Different Metabolic Responses to Long-term Weight Loss After Lifestyle Intervention Among Type 2 Diabetes Risk Clusters: Results From the TULIP Study. [PDF]

Diabetes
Meier CZ, Wagner R, Ganslmeier M, Kantartzis K, Heni M, Peter A, Jumpertz-von Schwartzenberg R, Machann J, Schick F, Birkenfeld AL, Häring HU, Fritsche A, Stefan N.   +12 more
europepmc   +1 more source

Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome.

Gastroenterology, 2012
A. Vrieze, E. van Nood, F. Holleman, J. Salojärvi, R. Kootte, J. Bartelsman, G. Dallinga-Thie, M. Ackermans, M. Serlie, R. Oozeer, M. Derrien, Anne Druesne, J. V. H. van Hylckama Vlieg, V. Bloks, A. Groen, H. Heilig, E. Zoetendal, E. Stroes, W. D. de Vos, J. Hoekstra, Max Nieuwdorp   +20 more
semanticscholar   +1 more source

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Insulin Hypersecretion and Increased Ectopic Fat in South Asian American Adolescents and Young Adults Compared With White and African American Peers: The CHARISMA Study. [PDF]

Diabetes Care
Hitt TA, Kelly A, Stefanovski D, Zemel BS, McCarter R, Yanek L, Zandieh G, Özdemir I, Kamel IR, Hui SCN, Barker P, Magge SN.   +11 more
europepmc   +1 more source

Human gut microbes impact host serum metabolome and insulin sensitivity

Nature, 2016
H. Pedersen, Valborg Gudmundsdottir, H. Nielsen, Tuulia Hyotylainen, T. Nielsen, B. Jensen, K. Forslund, F. Hildebrand, Edi Prifti, G. Falony, E. Chatelier, F. Levenez, J. Doré, I. Mattila, D. Plichta, Päivi Pöhö, L. Hellgren, Manimozhiyan Arumugam, S. Sunagawa, S. Vieira-Silva, T. Jørgensen, J. Holm, K. Trošt, MetaHIT consortium, K. Kristiansen, S. Brix, J. Raes, Jun Wang, T. Hansen, P. Bork, S. Brunak, M. Orešič, S. Ehrlich, O. Pedersen   +33 more
semanticscholar   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Insulin enables acquisition of the IL7R⁺ memory phenotype in PD1⁺ T cells in RA tissues. [PDF]

Cell Death Dis
Chandrasekaran V, Erlandsson MC, Svensson D, Malmhäll-Bah E, Silfverswärd ST, Pullerits R, Katona G, Bokarewa MI.   +7 more
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

Mechanisms of postpartum metabolic dysfunction-associated steatotic liver disease in women with a history of gestational diabetes mellitus. [PDF]

Endocr Connect
Li W, Zhang S, Huang Y, Shi R, Feng L.
europepmc   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source