Results 221 to 230 of about 2,632,133 (359)

Human gut microbes impact host serum metabolome and insulin sensitivity

Nature, 2016
H. Pedersen, Valborg Gudmundsdottir, H. Nielsen, Tuulia Hyotylainen, T. Nielsen, B. Jensen, K. Forslund, F. Hildebrand, Edi Prifti, G. Falony, E. Chatelier, F. Levenez, J. Doré, I. Mattila, D. Plichta, Päivi Pöhö, L. Hellgren, Manimozhiyan Arumugam, S. Sunagawa, S. Vieira-Silva, T. Jørgensen, J. Holm, K. Trošt, MetaHIT consortium, K. Kristiansen, S. Brix, J. Raes, Jun Wang, T. Hansen, P. Bork, S. Brunak, M. Orešič, S. Ehrlich, O. Pedersen   +33 more
semanticscholar   +1 more source

Size‐Modulated Mesoderm‐Endoderm Divergence and Myocardial Cavitation in Micropatterned Cardioids

Advanced Science, EarlyView.
Micropatterned cardioids, CRISPR‐engineered reporter hiPSCs, deep‐tissue imaging, and single‐cell RNA sequencing are integrated to model mesoderm‐endoderm co‐development. Heart‐foregut crosstalk promotes single large cavitation inside cardioids, resembling early heart chamber formation. ABSTRACT The human heart, originating from the splanchnic mesoderm,
Plansky Hoang, David W. McKellar, Andrew Kowalczewski, Nhu Y. Mai, Meng Chai, Xiaojun L. Lian, Yi Zheng, Jeffrey Amack, Nathan Tucker, Iwijn De Vlaminck, Huaxiao Yang, Benjamin D. Cosgrove, Zhen Ma   +12 more
wiley   +1 more source

Peripheral Insulin Resistance and Alzheimer's Disease: Possible Mediators Including Extracellular Vesicles. [PDF]

Geriatr Gerontol Int
Izuo N, Kondoh H, Shimizu T.
europepmc   +1 more source

Intensive insulin therapy and pentastarch resuscitation in severe sepsis.

New England Journal of Medicine, 2008
F. Brunkhorst, C. Engel, F. Bloos, A. Meier‑Hellmann, M. Ragaller, N. Weiler, O. Moerer, M. Gruendling, M. Oppert, S. Grond, D. Olthoff, U. Jaschinski, S. John, R. Rossaint, T. Welte, M. Schaefer, P. Kern, E. Kuhnt, M. Kiehntopf, C. Hartog, C. Natanson, M. Loeffler, K. Reinhart   +22 more
semanticscholar   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging. [PDF]

Aging Cell
Kojima D, Yaku K, Kosugi S, Mitsuno R, Kaneko K, Kawano Y, Hishikawa A, Mizuno S, Katoh M, Satoh A, Toyokuni S, Azegami T, Kinouchi K, Yamaguchi S, Itoh H, Kanda T, Yamauchi T, Nakagawa T, Hayashi K, Yoshino J.   +19 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Adipose Tissue Resistance to the Antilipolytic Effect of Insulin and Niacin in Humans With Obesity. [PDF]

Diabetes
Lin S, Lytle KA, Fink N, Jensen MD.
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Targeting Insulin Resistance Through Nutrition: Pathophysiological Insights and Dietary Interventions. [PDF]

Nutrients
Caretto A, Zanardini A, Frontino G, Pedone E.   +3 more
europepmc   +1 more source