Results 271 to 280 of about 1,058,875 (320)

Biomimetic Microstructured Scaffold with Release of Re‐Modified Teriparatide for Osteoporotic Tendon‐to‐Bone Regeneration via Balancing Bone Homeostasis

Advanced Science, EarlyView.
This study develops RPTH by re‐modifying teriparatide and designs a biomimetic microstructured scaffold (BMRP) loaded with RPTH to address osteoporotic tendon‐to‐bone interface repair. The BMRP restores tissue architecture by balancing bone homeostasis and remodeling the microstructure, achieving functional recovery in an osteoporotic rotator cuff tear
Chengzhong Xu, Sijie Qiu, Zhigen Yuan, Chongyin Qiu, Wenyu Xu, Jialiang Guo, Gen Wen, Shuai Liu, Wenjuan Yan, Haibing Xu, Honghao Hou, Dehong Yang   +11 more
wiley   +1 more source

Harnessing plant metabolic pathways for innovative diabetes management: unlocking the therapeutic potential of medicinal plants. [PDF]

Plant Signal Behav
Okechukwu Paul-Chima U, Chinyere Nkemjika A, Melvin Nnaemeka U, Onohuean H.   +3 more
europepmc   +1 more source

AKT1E17K‐Interacting lncRNA SVIL‐AS1 Promotes AKT1 Oncogenic Functions by Preferentially Blocking AKT1E17K Dephosphorylation

Advanced Science, EarlyView.
Wang et al. discover a novel lncRNA regulator of mutant oncoprotein which prevents AKT1E17K dephosphorylation. SVIL‐AS1 overexpression correlates with poor prognosis of breast cancer patients. It interacts with AKT1E17K protein and impedes PP2A holoenzyme from dephosphorylating AKT1 by blocking the binding of the regulatory subunit PPP2R2A to AKT1 ...
Jingyi Wang, Wenying Chen, Qianying Li, Ruiyi Yang, Xiaorong Lin, Ping Han, Xiaoming Huang, Hai Hu, Man‐Li Luo   +8 more
wiley   +1 more source

Design of a novel long-acting insulin analogs by acetylation modification and compared with insulin Icodec. [PDF]

Sci Rep
Yu M, Zhang C, Xu H, Dong Y, Zhu H, Xia C, Feng J.   +6 more
europepmc   +1 more source

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

Glucose metabolism after distal pancreatectomy - deterioration of beta cell function becomes noticeable at an early stage: a retrospective cohort study. [PDF]

BMC Surg
Kalandarishvili M, Oehme F, Radulova-Mauersberger O, Kipke N, Solimena M, Teske C, Mibelli N, Weitz J, Distler M, Hempel S.   +9 more
europepmc   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Nonlinear associations between METS-IR and all-cause as well as cardiovascular mortality in adults with osteoporosis and osteopenia: evidence from NHANES 2007-2023. [PDF]

Sci Rep
Liu Y, Yang Y, Li Y, Ding W, Yang X.
europepmc   +1 more source

Rabson-Mendenhall Syndrome Nearly Misdiagnosed as Type 1 Diabetes Mellitus: A Case Report. [PDF]

Cureus
Almotawa F, Mushiba AM, Alqahtani N, Mashi A.   +3 more
europepmc   +1 more source

Cardioprotective role of SIRT1 activation on mitochondrial function in insulin-resistant H9c2 cells. [PDF]

BMC Cardiovasc Disord
Sancak B, İnönü D, Alp G, Sağlam FT, Aryan L, Şık S, Akat F, Tuncay E.   +7 more
europepmc   +1 more source