Results 281 to 290 of about 2,129,772 (314)

Sex-specific phosphoproteome responses to calorie restriction and insulin in skeletal muscle from older rats. [PDF]

J Gerontol A Biol Sci Med Sci
Wang H, Madsen S, Needham EJ, Humphrey SJ, Zheng A, Arias EB, Stöckli J, Cutler HB, James DE, Cartee GD.   +9 more
europepmc   +1 more source

Deficiency of SCAMP5 Triggers Pancreatic β‐Cell Secretory Dysfunction and Apoptosis

Advanced Science, EarlyView.
This study demonstrates that hyperglycemia in diabetes activates ChREBP, which epigenetically represses SCAMP5 expression in pancreatic β‐cells. This SCAMP5 deficiency impairs insulin secretion by downregulating the calcium channel CaV1.2. Furthermore, reduced SCAMP5 triggers β‐cell apoptosis by stabilizing VDAC1 and enhancing its interaction with Bax,
Yingqi Zhang, Donglan Tang, Chenxi Yang, Chao Lin, Yingyue Yuan, Meiying He, Yiying Chen, Zhuo Mao, Ying Ying, Xiaosong Ma, Xiangchen Kong   +10 more
wiley   +1 more source

Practical considerations for using concentrated U200 insulin in automated insulin delivery systems. [PDF]

Front Endocrinol (Lausanne)
Marks BE, Chu PY, Parimi N, Wolf RM, Tran M, Berget C.   +5 more
europepmc   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Switch from premixed insulin analogue to degludec-liraglutide combination: a CGM study. [PDF]

Front Endocrinol (Lausanne)
Kravos Tramšek NA, Koceva A, Krajnc M.
europepmc   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

Advanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh, Albert Kallon Koroma, Rajeev Kumar Pandey, Yongfang Wang, Jinnan Cheng, Philipp Haas, Mahyar Aghapour, Linda Krug, Adelheid Hainzl, Meinhard Wlaschek, Pallab Maity, Karin Scharffetter‐Kochanek   +11 more
wiley   +1 more source

Glucose shields RINm5F beta cells against arsenic-induced apoptosis. [PDF]

Sci Rep
Ortiz-Huidobro RI, Pánico P, Salazar AM, Hiriart M, Ostrosky-Wegman P.   +4 more
europepmc   +1 more source

Effects of canagliflozin combined with metformin therapy on insulin sensitivity in patients with type 2 diabetes mellitus. [PDF]

Eur J Med Res
Shu Y, Chen X, Wang P.
europepmc   +1 more source

Systematic Review and Meta-Analysis of Insulin Dose and Route of Administration Regimens for Diabetic Ketoacidosis in Children and Adolescents. [PDF]

J Clin Med
Idrees H, Memon F, Alam R, Talal M, Ishaq A, Amjad F, Lang E, Soofi SB, Ariff S.   +8 more
europepmc   +1 more source

Case Report: Exogenous insulin antibody syndrome complicated with chronic renal failure and long-term history of type 2 diabetes: report of two cases. [PDF]

Front Endocrinol (Lausanne)
Hu Z, Huang X, Pan J, Dong H.
europepmc   +1 more source