Results 161 to 170 of about 584,894 (281)
Metformin and Severe Post‐COVID‐19 Outcomes Among Individuals With Diabetes Mellitus
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims We evaluated the relationship between metformin, one of the most commonly prescribed medications for individuals with diabetes, and COVID‐19 sequelae. Materials and Methods We evaluated a retrospective cohort of individuals in the National Clinical Cohort Collaborative with Type 2 diabetes mellitus and COVID‐19 who were prescribed ...
Zachary B. Dozier +148 more
wiley +1 more source
Glucocorticoid use may trigger secondary diabetes or exacerbate hyperglycemia in patients with diabetes mellitus (DM). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the treatment of patients with type 2 diabetes.
Zhang, Jiudan +4 more
core
The FEBS Journal, EarlyView.Host genetic variation in immune regulation and cell signalling genes was associated with microbiome composition across vaginal, gut, oral and skin sites, while associations involving metabolic function, epithelial barrier integrity and hormonal processes were more site‐specific. Overall, our findings indicate that host genetic variation contributes to
Isabella Margaret Davidson +4 more
wiley +1 more source
Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy
Immunology &Cell Biology, EarlyView.IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley +1 more source
Internal Medicine Journal, EarlyView.Abstract Background Evidence suggests that some medical emergencies in hospital are associated with preventable medication errors or adverse reactions. Aim The purpose of this case series was to investigate and describe the proportion of Medical Emergency Response Team (MERT) activations that are medication‐related, the degree of preventability and ...
Ian Coombes +9 more
wiley +1 more source
Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines
Immunology, EarlyView.This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw +10 more
wiley +1 more source
A unified formulation for home healthcare routing and scheduling problems
International Transactions in Operational Research, EarlyView.Abstract Home Healthcare is an essential component of healthcare systems, where caregivers visit patients' homes to deliver services. While presenting advantages with respect to institutional care, such as being cost‐effective and alleviating family burdens, it presents challenges in scheduling and routing caregivers efficiently.
Sara Ceschia +7 more
wiley +1 more source
Modulation of sebocyte function in acne: A pathway‐inclusive review
Journal of the European Academy of Dermatology and Venereology, EarlyView.Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis +3 more
wiley +1 more source