Results 51 to 60 of about 584,894 (281)

Loss of LCN2 Function Ameliorates Glucocorticoid‐Induced Muscle Atrophy via Remodeling the Extracellular Matrix

Advanced Science, EarlyView.
Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi, Xiaojing Hao, Yi Yan, Fengyang Li, Yaru Zhang, Zixin Li, Wenjuan Xie, Jiayin Lu, Xiaomao Luo, Yanjun Dong, Haidong Wang, Juan Wang   +11 more
wiley   +1 more source

Nicotinamide riboside and pterostilbene reduces markers of hepatic inflammation in NAFLD: A double‐blind, placebo‐controlled clinical trial

Hepatology, EarlyView., 2022
NRPT 1X reduces ALT and ceramide 14:0 in 65% of subjects as compared to only 28% in the placebo group. Abstract Background and Aims The prevalence of NAFLD is increasing globally and on a path to becoming the most frequent cause of chronic liver disease. Strategies for the prevention and treatment of NAFLD are urgently needed.
Ryan W. Dellinger, Holly E. Holmes, Tina Hu‐Seliger, Rodney W. Butt, Stephen A. Harrison, Dariush Mozaffarian, Oliver Chen, Leonard Guarente   +7 more
wiley   +1 more source

Lessons learned: using adverse incident reports to investigate the characteristics and causes of prescribing errors

BMJ Open Quality, 2020
Introduction Prescribing errors are a principal cause of preventable harm in healthcare. This study aims to establish a systematic approach to analysing prescribing-related adverse incident reports, in order to elucidate the characteristics and ...
Natalie Lane, Ian Hunter
doaj   +1 more source

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy [PDF]

, 2015
BACKGROUND: History and severity of atopic dermatitis (AD) are risk factors for peanut allergy. Recent evidence suggests that children can become sensitized to food allergens through an impaired skin barrier.
Sicherer, Scott, Brough, Helen A., Makinson, Kerry, Burks, Wesley, Turcanu, Victor, Jones, Stacie M., Liu, Andrew H., Lack, Gideon, Brown, Sara J., Sampson, Hugh, Wood, Robert A., Douiri, Abdel; id_orcid, Stablein, Donald, Dawson, Peter, Douiri, Abdel, McLean, W. H. Irwin, Stephens, Alick C., Irwin Mclean, W.h.   +17 more
core   +1 more source

Assessing the Mucosal Inflammatory Endotype of Obesity in Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory syndrome of the paranasal sinuses that is defined phenotypically as either with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). More recently, inflammatory markers have been used to cluster patients into putative endotypes that are presumed to have a common ...
Jeffanie W. Gayoso, Li‐Ching Huang, Quanhu Sheng, Daniel Lofgren, Ping Li, Katherine Cahill, Mason Krysinski, Rakesh K. Chandra, Justin H. Turner, Naweed Chowdhury   +9 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

IgE clonality and aggregation of insulin affect IgE-mediated activation of sensitized basophils

Journal of Allergy and Clinical Immunology: Global
Background: Skin prick testing and specific IgE determination do not discriminate between sensitization and clinically relevant insulin allergic reactions, whereas the basophil histamine release assay has proven useful in identifying clinically relevant ...
Steffen Christoffersen, MSc, Katrine Baumann, PhD, Anders Holm Millner, PhD, Henrik Toft-Hansen, PhD, Eva Johansson, PhD, Camilla Thorlaksen, PhD, Per Stahl Skov, PhD   +6 more
doaj   +1 more source

Updated grading system for systemic allergic reactions: Joint Statement of the World Allergy Organization Anaphylaxis Committee and Allergen Immunotherapy Committee [PDF]

Adverse events; Allergen immunotherapy; AnaphylaxisEventos adversos; Inmunoterapia con alérgenos; AnafilaxiaEsdeveniments adversos; Immunoteràpia amb al·lèrgens; AnafilaxiThere is a lack of consensus over the description and severity assignment of ...
Turner, Paul, Campbell, Dianne, Cardona, Victoria, Ansotegui Zubeldia, Ignacio Javier, Carr, Stuart, Custovic, Adnan, Ignacio J. Ansotegui, MD, PhD, WAO Anaphylaxis Committee and WAO Allergen Immunotherapy Committee, Ebisawa, Motohiro, Elham Hossny, MD, PhD, Guillaume Pouessel, MD, Greenberger, Paul A., Morais-Almeida, Mário, Levin, Michael E., Turner, Paul J, Campbell, Dianne E, Ortega Martell, José Antonio, Senna, Gianenrico, Worm, Margitta, Victoria Cardona, MD, PhD, Motohiro Ebisawa, MD, PhD, Muraro, Antonella, Durham, Stephen, Mario Geller, MD, Geller, Mario, Adnan Custovic, MD, PhD, José Antonio Ortega Martell, MD, Manuel J. Rial, MD, PhD, Leung, Agnes S.Y., Gianenrico Senna, MD, PhD, Alexei Gonzalez-Estrada, MD, Antonella Muraro, MD, Rial, Manuel J., Ansotegui, Ignacio J, Stephen Durham, MD, Irani, Carla, Pouessel, Guillaume, Agnes S.Y. Leung, MD, Paul J. Turner, MD, PhD, Campbell, Dianne E., Tanno, Luciana K., Leung, Agnes SY, Greenberger, Paul A, Tanno, Luciana K, Rial, Manuel J, Dana V. Wallace, MD, Oppenheimer, John J, Luciana K. Tanno, MD, PhD, Turner, Paul J., Wallace, Dana V., Wallace, Dana V, Dianne E. Campbell, MD, PhD, Carla Irani, MD, Mário Morais-Almeida, MD, PhD, Paul A. Greenberger, MD, Ansotegui, Ignacio J., Michael E. Levin, MD, PhD, Margitta Worm, MD, PhD, Stuart Carr, MD, Levin, Michael E, Hossny, Elham, John J. Oppenheimer, MD, Gonzalez-Estrada, Alexei, Oppenheimer, John J.   +63 more
core   +1 more source

Developments allergy in 2019 through the eyes of Clinical and Experimental Allergy, Part II clinical allergy

, 2020
In the second of two linked articles, we describe the development in clinical as described by Clinical & Experimental Allergy and other journals in 2019. Epidemiology, clinical allergy, asthma and rhinitis are all covered.
Crane, J., Roberts, Graham, Almqvist, C, Marsland, B., S. Saglani, Marsland, B, R. Boyle, Woodfolk, J.A., Saglani, S., Woodfolk, J. A., J. Crane, S.P. Hogan, C. Almqvist, Graham Roberts, Boyle, R, B. Marsland, Saglani, S, Hogan, S.P., Woodfolk, JA, Hogan, S. P., Hogan, SP, J.A. Woodfolk, Roberts, G, Crane, J, Almqvist, C., Boyle, R.   +25 more
core   +1 more source

The increase of plasma galectin-9 in a patient with insulin allergy: a case report [PDF]

, 2010
Allergic reaction to insulin is known to be associated with eosinophilia and hyper IgE. Recent report showed that eosinophilia is related with the increased synthesis of galectin-9 (GAL-9) and osteopontin (OPN).
Siddiqi Umme, Haorile Chagan-Yasutan, Yugo Ashino, Tomohiro Arikawa, Mitsuomi Hirashima, Umme Ruman Siddiqi, Hattori Toshio, Chagan-Yasutan Haorile, Ashino Yugo, Saitoh Hiroki, Shiratori Beata, Umme Siddiqi, Hirashima Mitsuomi, Hiroki Saitoh, Beata Shiratori, Arikawa Tomohiro, Toshio Hattori   +16 more
core   +1 more source