Results 21 to 30 of about 411,749 (186)
A subcutaneous insulin pharmacokinetic model for insulin Detemir [PDF]
, 2020 Background and Objective: Type 2 diabetes (T2D) is rapidly increasing in incidence and has significant social and economic costs. Given the increasing cost of complications, even relatively short delays in the onset of T2D can significantly reduce long ...
Knopp JL, Chase, Geoff, van Noorden B
core +1 more source
Therapeutic Advances in Endocrinology and Metabolism, 2012 The three currently marketed long-acting insulin analogs, glargine, detemir and insulin lispro protamine suspension (ILPS), represent the most significant advances in basal insulin supplementation since the 1940s and 1950s and the introduction of the ...
Dario Giugliano, Katherine Esposito
doaj +1 more source
All-Cause and Cause-Specific Mortality among Users of Basal Insulins NPH, Detemir, and Glargine. [PDF]
PLoS ONE, 2016 BACKGROUND:Insulin therapy in type 2 diabetes may increase mortality and cancer incidence, but the impact of different types of basal insulins on these endpoints is unclear.
Arto Y Strandberg +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 The management of diabetes mellitus in an insulin-dependent patient is challenging in the setting of concomitant antibody-mediated-insulin hypersensitivity.
Chong Boon Teo +14 more
doaj +1 more source
Molecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10. [PDF]
PLoS ONE, 2012 AIMS/HYPOTHESIS: There is controversy with respect to molecular characteristics of insulin analogues. We report a series of experiments forming a comprehensive characterisation of the long acting insulin analogues, glargine and detemir, in comparison ...
Bo F Hansen +6 more
doaj +1 more source
The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli +3 more
wiley +1 more source
Insulin detemir: From concept to clinical experience
Insulin detemir (Levemir\uae, Novo Nordisk) is a novel, biologically engineered analogue of human insulin that has been successfully developed for clinical use in diabetes as a basal insulin.
Kurtzhals P, Home P
core +5 more sources
Insulin Antibody-induced Diabetic Ketoacidosis in an Elderly Type 2 Diabetic Ameliorated with Prednisolone [PDF]
Journal of Clinical and Diagnostic Research, 2018 In the patients who are treated with insulin, the synthesis of insulin antibodies occasionally induce difficulty in glycaemic management. Insulin antibodies are now being closely examined in the context of diabetes treatment.
Yuko Matsumoto +4 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia +6 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7791-7801, September 2026.ABSTRACT Aims ONWARDS 10 assessed switching from daily basal insulins to once‐weekly insulin icodec without a one‐time additional dose at first injection. Materials and Methods In this treat‐to‐target, open‐label, 26‐week, phase 3b trial, adults with basal‐insulin‐treated type 2 diabetes (T2D) with glycated haemoglobin [HbA1c] 7.0%–10.0% were ...
Julio Rosenstock +5 more
wiley +1 more source