Results 41 to 50 of about 411,749 (186)

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

open access: yesAdvanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Long-acting insulin allergy in a diabetic child

open access: yesInternational Journal of Immunopathology and Pharmacology, 2017
Insulin allergy has been uncommon since the introduction of human recombinant insulin preparations; the prevalence is 2.4%. Insulin injection could elicit immediate reactions, which are usually induced by an IgE-mediated mechanism, within the first hour ...
Carla Mastrorilli   +5 more
doaj   +1 more source

Effects of insulin and analogues on carcinogen-induced mammary tumours in high-fat-fed rats

open access: yesEndocrine Connections, 2018
It is not fully clarified whether insulin glargine, an analogue with a high affinity for insulin-like growth factor-1 receptor (IGF-1R), increases the risk for cancers that abundantly express IGF-1R such as breast cancer or some types of breast cancer ...
Yusaku Mori   +8 more
doaj   +1 more source

The Effect of Basal Analog Insulin on the Glycemic Variability in Type 2 Diabetics

open access: yesEndocrinology Research and Practice, 2014
Purpose: The aim of this study was to investigate the effect of insulin detemir and glargine on glycemic variability as determined by capillary blood glucose measurements in Type 2 diabetics treated with oral antidiabetic drugs.
Soner Cander   +4 more
doaj   +1 more source

Measuring the Impact of the Substitution of Innovator Biologics With Biosimilars on Uptake and Costs Among Ontario Public Drug Benefit Recipients

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1476-1484, June 2026.
In Ontario, biologics have historically represented a small proportion of public drug claims but a large proportion of spending. Biosimilars, lower cost alternatives to biologics, offer a potential solution to the rising spending on biologics. From March 2023 to January 2024, the Ontario Ministry of Health required public drug program beneficiaries on ...
Anita Iacono   +10 more
wiley   +1 more source

Insulin detemir versus insulin glargine for type 2 diabetes mellitus

open access: yes, 2011
Chronically elevated blood glucose levels are associated with significant morbidity and mortality. Many diabetes patients will eventually require insulin treatment to maintain good glycaemic control.
Hoekstra, Joost B.   +4 more
core   +1 more source

Subclinical respiratory dysfunction in neonates born to diabetic mothers and its association with cord blood adipokines

open access: yesPediatric Allergy and Immunology, Volume 37, Issue 6, June 2026.
Maternal diabetes impairs fetal lung maturation, creating subclinical respiratory risks at birth. The study compared 37 newborns of diabetic mothers against 40 healthy controls using cord blood analysis and tidal breath measurements. Results showed elevated leptin alongside decreased ghrelin and adiponectin levels.
Simge Atar Bese   +9 more
wiley   +1 more source

A call to action: A consensus statement on knowledge gaps and research priorities on the management of women with early onset type 2 diabetes in the preconception, pregnancy and postnatal periods

open access: yesDiabetic Medicine, Volume 43, Issue 5, May 2026.
Abstract Aims Research to inform, co‐develop and evaluate optimal care for women with early‐onset type 2 diabetes (EOT2D) before, during and after pregnancy is lacking. Informed by patient perspectives and the results of the James Lind Alliance priority‐setting partnership in diabetes in pregnancy, we aimed to develop a consensus statement to guide ...
Sara L. White   +8 more
wiley   +1 more source

Insulin analogues versus human insulin in type 1 diabetes: direct and indirect meta-analyses of efficacy and safety

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2013
All patients with Diabetes Mellitus (DM) receive insulin therapy. In this study, we evaluated the efficacy, safety and tolerability of human insulin and insulin analogues.
Andréia Cristina Conegero Sanches   +6 more
doaj   +1 more source

Cost‐utility of once‐weekly insulin icodec versus once‐daily basal insulins for type 2 diabetes in China

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3872-3882, May 2026.
Abstract Objective To comprehensively assess the cost‐utility of icodec, the first once‐weekly basal insulin, at 700 and 1050 U formulations compared with once‐daily basal insulin analogues in Chinese adults with type 2 diabetes within reimbursement context.
Xichen Tong   +3 more
wiley   +1 more source

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