Results 91 to 100 of about 115,305 (240)

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Palatability, glycemic, and insulinemic responses to various carbohydrate formulations: Alternatives for the diagnosis of insulin dysregulation in horses? [PDF]

J Vet Intern Med, 2023
Warnken T, Schaub C, Delarocque J, Frers F, Feige K, Sonntag J, Reiche DB.   +6 more
europepmc   +1 more source

Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice

Diabetes
Cancer survivors have an increased risk of developing type 2 diabetes compared with the general population. Patients treated with cisplatin, a common chemotherapeutic agent, are more likely to develop metabolic syndrome and type 2 diabetes than age- and sex-matched control patients.
Lahari Basu, Lili Grieco-St-Pierre, Ma. Enrica Angela Ching, John D.H. Stead, Antonio A. Hanson, Jana Palaniyandi, Erin van Zyl, Myriam P. Hoyeck, Kelsea S. McKay, Kyle A. van Allen, Hyojin Lee, Xiao-Qing Dai, Austin Bautista, Evgenia Fadzeyeva, Erin E. Mulvihill, Carole L. Yauk, Jan A. Mennigen, Patrick E. MacDonald, Jennifer E. Bruin   +18 more
openaire   +2 more sources

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Plasma Amino Acid Concentration in Obese Horses with/without Insulin Dysregulation and Laminitis. [PDF]

Animals (Basel), 2022
Stoeckle SD, Timmermann D, Merle R, Gehlen H.   +3 more
europepmc   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Value of measuring markers of lipid metabolism in horses during an oral glucose test

Journal of Veterinary Internal Medicine
Background Characterizing the lipid response to an oral glucose test (OGT) might improve our understanding of Equine Metabolic Syndrome. Hypothesis/Objectives To describe the effects of an OGT on lipid metabolism and determine the value of measuring ...
Claire H. K. Zemek, Kate L. Kemp, François‐René Bertin   +2 more
doaj   +1 more source

Thromboelastography in obese horses with insulin dysregulation compared to healthy controls. [PDF]

J Vet Intern Med, 2022
Lovett AL, Gilliam LL, Sykes BW, McFarlane D.   +3 more
europepmc   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

Insulin dysregulation drives mitochondrial cholesterol metabolite accumulation: initiating hepatic toxicity in nonalcoholic fatty liver disease. [PDF]

J Lipid Res, 2023
Minowa K, Rodriguez-Agudo D, Suzuki M, Muto Y, Hirai S, Wang Y, Su L, Zhou H, Chen Q, Lesnefsky EJ, Mitamura K, Ikegawa S, Takei H, Nittono H, Fuchs M, Pandak WM, Kakiyama G.   +16 more
europepmc   +1 more source