Results 101 to 110 of about 533,242 (221)

Inflammation, mechanical allodynia and an exaggerated exercise pressor reflex during disease progression in UCD‐type 2 diabetes mellitus rats

Experimental Physiology, EarlyView.
Abstract Chronic low‐grade inflammation characterizes type 2 diabetes mellitus (T2DM) and underlies the development of peripheral neuropathy, symptoms of which include mechanical allodynia and an exaggerated exercise pressor reflex. The purpose of this study was to determine whether mechanical allodynia and/or specific concentrations of inflammatory ...
Michelle L. Harrison, Richard K. McCuller, Yu Huo, Amshula N. Gajula, Kai Ybarbo, Mark J. Van Ryzin, Kimber L. Stanhope, Peter J. Havel, Audrey J. Stone   +8 more
wiley   +1 more source

Knockdown of mitotically associated long non‐coding RNA dysregulates endothelial functions, transcriptome and proteome

The Journal of Physiology, EarlyView.
Abstract figure legend Downregulation of mitotically associated long non‐coding RNA (MANCR) disturbs transcriptome and proteome in endothelial cells, possibly leading to endothelial and vascular dysfunction in preeclampsia. Abstract Preeclampsia (PE) is a hypertensive disorder during pregnancy, which is characterized by a wide spectrum of endothelial ...
Si‐Yan Zhang, Chi Zhou, Jing Zheng
wiley   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Acute coronary syndrome in diclofenac sodium-induced type I hypersensitivity reaction : Kounis syndrome [PDF]

, 2007
Drug-induced type I hypersensitivity reactions are frequent. Sometimes, acute coronary syndrome (ACS) can be registered in such patients, which may have a serious impact on the course and management of the allergic reaction.
Panic, Milos, Putnikovic, Biljana, Jankovic-Gavrilovic, Jelena, Rasic-Milutinovic, Zorica, Gluvic, Zoran M., Stojkovic, Aleksandra   +5 more
core  

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11143-11177, December 2026.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis.

, 2014
Tissue-specific knockout (KO) of atypical protein kinase C-λ (PKC-λ) impairs insulin-stimulated glucose transport in muscle (M) and lipid synthesis in liver (L), thereby producing insulin resistance in MλKO mice and insulin-hypersensitivity in LλKO mice.
Jurzak, MJ, Shulman, GI, Farese, Robert, Farese, RV, Samuels, VT, Braun, U, Leitges, M, Sajan, MP   +7 more
core  

In vivo Metabolic Imaging of Insulin with Multiphoton Fluorescence of Human Insulin-Au Nanodots

, 2014
Functional human insulin-Au nanodots (NDs) are synthesized for the in vivo imaging of insulin metabolism. Benefiting from its efficient red to near infrared fluorescence, deep tissue subcellular uptake of insulin-Au NDs can be clearly resolved through a ...
王宗道 ;許榮彬 ;林昭維, Liu, Chien-Liang;Liu, Tzu-Ming;Hsieh, Tsung-Yuan;Liu, Han-Wen;Chen, Yu-Shing;Tsai, Cheng-Kun;Chen, Hsieh-Chih;Lin, Jong-Wei;Hsu, Ron-Bin;Wang, Tzung-Dau;Chen, Chien-Cheng;Sun, Chi-Kuang;Chou, Pi-Tai   +1 more
core   +1 more source

Once‐Weekly Insulin Versus Once‐Daily Insulin for Type 1 Diabetes Treatment: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials

Endocrinology, Diabetes & Metabolism
Background Type 1 diabetes mellitus (T1DM) represents a considerable global health burden, affecting approximately 5%–10% of individuals with diabetes. Once‐weekly basal insulin could substantially reduce the number of injections for T1DM patients from ...
Obieda Altobaishat, Ahmed Farid Gadelmawla, Suliman Almohtasib, Husam Abu Suilik, AlMothana Manasrah, Mohamed Abouzid, Mustafa Turkmani, Mohamed Abuelazm   +7 more
doaj   +1 more source

A 52‐Week Efficacy and Safety Study of Teneligliptin, as an Add‐On to Empagliflozin and Metformin in Patients With Type 2 Diabetes Mellitus: A Randomised, Double‐Blind, Placebo‐Controlled Phase 3 Trial (TERA305 Study)

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11955-11965, December 2026.
ABSTRACT Aims To evaluate the long‐term efficacy and safety of teneligliptin add‐on in patients with type 2 diabetes mellitus (T2DM) inadequately controlled with metformin and empagliflozin. Materials and Methods In this randomised, double‐blind, phase 3 trial, 214 patients received teneligliptin 20 mg (n = 107) or placebo (n = 107) once daily for 24 ...
Jun Sung Moon, Kyung Ah Han, Dong‐Lim Kim, Sang Yong Kim, Soo‐Kyung Kim, Bon Jeong Ku, Woo Je Lee, Tae Keun Oh, Ji A Seo, Sang‐Ah Chang, Moon‐Kyu Lee, Kyu Jeung Ahn, Chul Sik Kim, Tae Nyun Kim, Bong‐Soo Cha   +14 more
wiley   +1 more source

Managing Type 1 Diabetes in Neurodiverse Children and Young People: A Qualitative Exploration of Complexity and Care Challenges

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11432-11439, December 2026.
ABSTRACT Background Neurodiversity is an umbrella term encompassing multiple diagnoses including attention‐deficit/hyperactivity disorder (ADHD) and autistic spectrum conditions. Current research is limited but highlights the complexities faced by caregivers who often face unique challenges in managing Type 1 diabetes (T1D).
Zoe Tattersall, Sze May Ng
wiley   +1 more source